Patents by Inventor Robert Carl Brothers

Robert Carl Brothers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkenyl and beta-substituted phosphonates as antimicrobial agents
    Patent number: 11098072
    Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 24, 2021
    Assignees: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, Washington University, George Mason University, St. Louis University
    Inventors: Cynthia Dowd, Xu Wang, Robert Carl Brothers, Audrey Ragan Odom John, Rachel Edwards, Marvin Meyers, Stacy Arnett, Robin Couch, Kenneth Heidel
  • NOVEL ALKENYL AND BETA-SUBSTITUTED PHROSPHONATES AS ANTIMICROBIAL AGENTS
    Publication number: 20200140469
    Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.
    Type: Application
    Filed: June 27, 2018
    Publication date: May 7, 2020
    Applicants: The George Washington University, Washington University in St. Louis, George Mason University, Saint Louis University
    Inventors: Cynthia Dowd, Xu WANG, Robert Carl BROTHERS, Audrey Ragan Odom JOHN, Rachel EDWARDS, Marvin MEYERS, Stacy ARNETT, Robin COUCH, Kenneth HEIDEL
  • Iodinated polymers for biological agent defeat
    Patent number: 10342232
    Abstract: A binder, and related processes, has been developed for biological agent defeat formulations. This highly iodinated binder is based on the polymer polyethylene tetraiodoterephthalamide. The materials have been formulated with metal fuel particles, such as aluminum, and various oxidizers, such as metal oxides. The binder-thermite composites may be actuated to initiate oxidation, therein generating heat. Upon thermal decomposition of these materials, iodine, a biocide, is released allowing for sterilization of biological agents.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: July 9, 2019
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Robert Carl Brothers, Rebecca Martin Wilson, Michelle Pantoya