Abstract: The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

Abstract: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Abstract: A method, computer program product and computer system is disclosed that generates a set of distributed representation vectors from a dataset of textual and non-text data. In one method, a computer system receives a dataset, cleans the received dataset, parses the cleaned dataset to identify known classes of data, extracts data elements from the dataset based on the known classes of data, organizes the extracted data elements into one or more records, compiles a dictionary of unique data elements and associated codes from the one or more records, creates a set of training pairs using permutations of the codes that correspond to data elements within each record, and computes a distributed representation vector for each of the data elements in the dictionary using the set of training pairs.

Abstract: A method, computer program product and computer system is disclosed that generates a set of distributed representation vectors from a dataset of textual and non-text data. In one method, a computer system receives a dataset, cleans the received dataset, parses the cleaned dataset to identify known classes of data, extracts data elements from the dataset based on the known classes of data, organizes the extracted data elements into one or more records, compiles a dictionary of unique data elements and associated codes from the one or more records, creates a set of training pairs using permutations of the codes that correspond to data elements within each record, and computes a distributed representation vector for each of the data elements in the dictionary using the set of training pairs.

Abstract: An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.

Abstract: A method, computer program product and computer system is disclosed that generates a set of distributed representation vectors from a dataset of textual and non-text data. In one method, a computer system receives a dataset, cleans the received dataset, parses the cleaned dataset to identify known classes of data, extracts data elements from the dataset based on the known classes of data, organizes the extracted data elements into one or more records, compiles a dictionary of unique data elements and associated codes from the one or more records, creates a set of training pairs using permutations of the codes that correspond to data elements within each record, and computes a distributed representation vector for each of the data elements in the dictionary using the set of training pairs.

Abstract: Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Abstract: A method, computer program product and computer system is disclosed that generates a set of distributed representation vectors from a dataset of textual and non-text data. In one method, a computer system receives a dataset, cleans the received dataset, parses the cleaned dataset to identify known classes of data, extracts data elements from the dataset based on the known classes of data, organizes the extracted data elements into one or more records, compiles a dictionary of unique data elements and associated codes from the one or more records, creates a set of training pairs using permutations of the codes that correspond to data elements within each record, and computes a distributed representation vector for each of the data elements in the dictionary using the set of training pairs.

Abstract: The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.

Abstract: The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: Power management notifications are provided to a user of a portable electronic device by monitoring a current power level of a power supply in a portable electronic device. A determination is made, with the portable electronic device, whether the current power level is one of less than and equal to a given threshold. One or more wireless detection operations are performed to determine whether a power supply charging device is in proximity to the portable electronic device. The power supply charging device is unattached to the portable electronic device. A notification is presented at the portable electronic device, in response to both the current power level is determined to be one of less than and equal to the given threshold, and the power supply charging device being wirelessly detected in proximity to the portable electronic device.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: Devices, systems and methods for facilitating interactions between individuals are disclosed. The exemplary method may include providing member facility information and allowing other members to review the facility information. Members may request a meeting with another member with details of the requested meeting via the system. The request is transmitted to another member and the other member may accept, deny, or modify the request by the other member. Members may have an other members inclusive list or other members exclusive list to assist in facilitating interactions. Ratings may be used to rate other members and interaction facilities to aid in facilitating future interactions.

Abstract: A method and a plurality of communication devices configured to control notification of reception of a same message by at least one of the plurality of communication devices. The method includes determining that a plurality of communication devices are in proximity with each other, determining that a same message was received by the plurality of communication devices, and determining at least one communication device of the plurality of communication devices on which to inhibit producing a notification that indicates the message was received. The at least one communication device delays a pre-determined amount of time while monitoring for reception of a signal that indicates the message was read, and based on determination that the delay of the pre-determined amount of time has expired and that the communication device has failed to receive the signal, the communication device produces the notification.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: A method and a plurality of communication devices configured to control notification of reception of a same message by at least one of the plurality of communication devices. The method includes determining that a plurality of communication devices are in proximity with each other, determining that a same message was received by the plurality of communication devices, and determining at least one communication device of the plurality of communication devices on which to inhibit producing a notification that indicates the message was received. The at least one communication device delays a pre-determined amount of time while monitoring for reception of a signal that indicates the message was read, and based on determination that the delay of the pre-determined amount of time has expired and that the communication device has failed to receive the signal, the communication device produces the notification.

Abstract: An apparatus and method for the automated preparation of treated monolayers of sample material, comprising: a centrifuge having a rotor (12) carrying removable chamber blocks (14); sample and reagent dispensers (26) and control systems (20). First, centrifugal force sediments sample material discretely to form a monolayer onto a receiving surface member (32) on one of the chamber blocks (14), while the same centrifugal force opens a valve (48) in the chamber block (14) to drain sample material. Then, centrifugal force delivers sequentially into discrete chamber blocks (14) discrete treating agents, during which time the sampler material monolayer is held in place on the receiving surface member (32) by centrifugal force. Then, each chamber block (14) is drained centrifugally through its already opened valve (48). Each treated sampler material is confined to an individual chamber block (14). Batch and random access delivery of treating agents can be employed.