Abstract: A computerized method of automatically capturing an image of a structure of interest in a tissue sample. The computer memory receives a first pixel data set representing an image of the tissue sample at a low resolution and an identification of a tissue type of the tissue sample, and selecting at least one structure-identification algorithm responsive to the tissue type from a plurality of structure-identification algorithms, at least two of which are responsive to different tissue types. Each structure-identification algorithm correlates at least one cellular pattern in a given tissue type with a presence of a structure of interest for the given tissue type. The method also includes applying the selected structure-identification algorithm to the first pixel data set to determine a presence of the structure of interest in the tissue sample, and capturing a second pixel data set at a high resolution.