Patents by Inventor Robert Cedergren

Robert Cedergren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid ribozymes and methods of use
    Patent number: 5942395
    Abstract: New hybrid ribozymes that exhibit the high metabolic stability of small nucleolar ribonucleic acids (snoRNAs), and that cleave target sequences with high efficiencies in either cis (intra-molecular) or trans (inter-molecular) configuration are described. The hybrid ribozymes include (i) a ribozyme catalytic sequence; and (ii) a snoRNA stabilizing motif; wherein the catalytic sequence and the stabilizing motif are arranged to provide the RNA molecule with a three-dimensional configuration in which the catalytic sequence is positioned to interact with a target sequence and the stabilizing motif adopts a conformation that stabilizes the RNA molecule, and additionally enables the RNA molecule to localize in the nucleolus of a cell.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: August 24, 1999
    Assignees: Universite de Montreal, University of Massachusettes
    Inventors: Maurille J. Fournier, Dmitry A. Samarsky, Gerardo Ferbeyre, Robert Cedergren