Patents by Inventor Robert Charles Ladner

Robert Charles Ladner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Libraries of genetic packages comprising novel HC CDR3 designs
    Patent number: 11926926
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: March 12, 2024
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Robert Charles Ladner
  • LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR1, CDR2, AND CDR3 AND NOVEL LC CDR1, CDR2, AND CDR3 DESIGNS
    Publication number: 20230340697
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Application
    Filed: January 27, 2023
    Publication date: October 26, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventor: Robert Charles Ladner
  • Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
    Patent number: 11598024
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: March 7, 2023
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Robert Charles Ladner
  • Display library process
    Patent number: 11479877
    Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: October 25, 2022
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Robert Charles Ladner, Shannon Hogan, Kristin L. Rookey
  • Prevention and reduction of blood loss
    Patent number: 11344610
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: May 31, 2022
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
  • NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF PEPTIDES, POLYPEPTIDES OR PROTEINS AND THE NOVEL LIBRARIES
    Publication number: 20210087256
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: August 4, 2020
    Publication date: March 25, 2021
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR3 DESIGNS
    Publication number: 20200399785
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Application
    Filed: June 9, 2020
    Publication date: December 24, 2020
    Applicant: Dyax Corp.
    Inventor: Robert Charles Ladner
  • Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
    Patent number: 10829541
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: November 10, 2020
    Assignee: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR1, CDR2, AND CDR3 AND NOVEL LC CDR1, CDR2, AND CDR3 DESIGNS
    Publication number: 20200347117
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Application
    Filed: April 2, 2020
    Publication date: November 5, 2020
    Applicant: Dyax Corp.
    Inventor: Robert Charles Ladner
  • FOCUSED LIBRARIES OF GENETIC PACKAGES
    Publication number: 20200325469
    Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
    Type: Application
    Filed: February 13, 2020
    Publication date: October 15, 2020
    Applicant: Dyax Corp.
    Inventor: Robert Charles Ladner
  • DISPLAY LIBRARY PROCESS
    Publication number: 20200231962
    Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.
    Type: Application
    Filed: January 21, 2020
    Publication date: July 23, 2020
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Shannon Hogan, Kristin L. Rookey
  • Libraries of genetic packages comprising novel HC CDR3 designs
    Patent number: 10718066
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 21, 2020
    Assignee: Dyax Corp.
    Inventor: Robert Charles Ladner
  • Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
    Patent number: 10683342
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: June 16, 2020
    Assignee: Dyax Corp.
    Inventor: Robert Charles Ladner
  • Focused libraries of genetic packages
    Patent number: 10604753
    Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: March 31, 2020
    Assignee: Dyax Corp.
    Inventor: Robert Charles Ladner
  • Display library process
    Patent number: 10577598
    Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: March 3, 2020
    Assignee: Dyax Corp.
    Inventors: Robert Charles Ladner, Shannon Hogan, Kristin L. Rookey
  • PREVENTION AND REDUCTION OF BLOOD LOSS
    Publication number: 20190247477
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: February 21, 2019
    Publication date: August 15, 2019
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
  • Prevention and reduction of blood loss
    Patent number: 10245307
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: April 2, 2019
    Assignee: Dyax Corp.
    Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
  • FOCUSED LIBRARIES OF GENETIC PACKAGES
    Publication number: 20180291368
    Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
    Type: Application
    Filed: October 30, 2017
    Publication date: October 11, 2018
    Applicant: Dyax Corp.
    Inventor: Robert Charles Ladner
  • LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR3 DESIGNS
    Publication number: 20180251912
    Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
    Type: Application
    Filed: December 8, 2017
    Publication date: September 6, 2018
    Applicant: Dyax Corp.
    Inventor: Robert Charles Ladner
  • NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF PEPTIDES, POLYPEPTIDES OR PROTEINS AND THE NOVEL LIBRARIES
    Publication number: 20170369557
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 28, 2017
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom