Abstract: Aspects of the disclosure relate to providing transportation services with autonomous vehicles. For instance, a first route to a first destination may be determined. The first route may have a first cost. Weather information for the first destination may be received. A characteristic is determined based on the weather information. A second destination having the characteristic may be selected. The second destination may be different from the first destination. A second route to the second destination may be determined. The second route may have a second cost. The first cost may be compared to the second cost, and the vehicle may use the comparison to set one of the first destination or the second destination as a current destination for a vehicle to cause the vehicle to control itself in an autonomous driving mode to the current destination.

Abstract: A caster board can include a front platform section connected by a torsion bar or other neck portion to a rear platform section. The caster board can be convertible between a first configuration in which the caster board has three wheels, and a second configuration in which the caster board has two wheels. In the first configuration, the rear platform section can be supported by two wheels laterally offset from a longitudinal axis of the caster board. In the second configuration, the rear platform section can be supported by one wheel aligned with a longitudinal axis of the caster board. The rear platform section can include at least three mounting locations configured to have caster assemblies installed therein.

Abstract: A vehicle may include a pedal assembly, a motor assembly, and a drive unit that may be used to allow selective usage of one or both of the pedal assembly and the motor assembly to convey power to a driven wheel of the vehicle. The drive unit can include a gearbox that may enclose components which form at least part of a first power path between the pedal assembly and the driven wheel and a second power path between the motor assembly and the driven wheel. The first and second power paths can converge at a component within the gearbox. One-way bearings at points in the first and second power paths prior to the convergence of the power paths can inhibit or prevent the pedal assembly from being affected by operation of the motor assembly, and vice versa.

Abstract: Various personal mobility vehicles, such as scooters, are disclosed. The scooter can include at least one battery and motor for powering at least one driven wheel. The vehicle can include a gear assembly to convert a torque produced by the motor to a different torque to a driven shaft to power the at least one driven wheel. The battery can be removable.

Abstract: An electric powered personal mobility vehicle that includes at least one front wheel and an electric motor that provides rotational force to a wheel of the vehicle. The electric motor is supported by the vehicle and is powered by a rechargeable battery that is also supported by the vehicle. The vehicle can also include swivel caster wheels each configured to rotate about a wheel axis.

Abstract: The present disclosure relates to compositions and methods for improving protein translation from recombination circular RNAs. In particular, provided herein are formulations for delivery of recombinant circular RNA (circRNA) molecules and circRNAs comprising viral and/or synthetic internal ribosome entry sites (IRESs), as well as methods for use thereof.

Abstract: A method to classify heart murmurs as benign or pathologic. A digitized acoustic heart signature of a patient is captured on a computing device and processed using Fast Fourier Transformation to identify a plurality of component frequency waveforms, each having a power value. Based on the waveforms' power values, they are classified into a primary frequency waveform, harmonic frequency waveforms, and non-harmonic frequency waveforms. The heart murmur of the patient is classified using a ratio of the power values of the harmonic waveforms as a portion of the composite power value of all the waveforms, and an interface indication is provided to the user of the computing device. A computing device and software program per the invention are also disclose.

Abstract: A system includes a chuck configured to accept a sample block, a blade including a blade surface configured to remove a tissue section from the sample block, where the chuck is moveable relative to the blade surface of the blade, at least one sensor configured to sense a front face of the sample block, and a control system. The control system is configured to receive measurements from the at least one sensor, identify, from the measurements, a geometry of the front face, identify, based on the geometry, an alignment of the front face with respect to the blade surface of the blade, and cause the chuck or the blade to move relative to each other to align the front face relative to the blade surface.

Abstract: Immunoglobulin complementarity determining regions (“CDRs”), and immunoglobulin binding domains comprising those CDRs, that bind human lymphocyte antigen 6 family member G6D (LY6G6D), and their use for the preparation of LY6G6D-binding proteins finding use as immunotherapeutics.

Abstract: A method includes obtaining road patch type data associated with at least one road patch type, deriving, from the road patch type data, a set of road patch type parameters for the at least one road patch type, identifying, based at least in part on the set of road patch type parameters, a set of autonomous vehicle (AV) motion planning constraints selected for the at least one road patch type, and providing the set of AV motion planning constraints to update motion planning functionality performed by at least one component of an AV.

Abstract: An interactive system can utilize microtechnology (e.g., a micro-electromechanical system (MEMS)), such as miniaturized microphone (e.g., a bone-conducting microphone), audio output device, microprocessor, and signal conversion and propagation means to create a personal area network (PAN) for a user. The system can include a voice input device (e.g., worn on one or more teeth of the user) that outputs a near-field magnetic induction (NFMI) signal based on a whisper input by the user. The NFMI signal is either detected by the user's mobile device, or converted into a wireless signal (e.g., a Bluetooth RF signal) detectable by the user's mobile device, for receiving voice commands (e.g., to provide personal assistant services) via a designated application running on the mobile device.

Abstract: A caster board can include a front platform section connected by a torsion bar or other neck portion to a rear platform section. The caster board can be convertible between a first configuration in which the caster board has three wheels, and a second configuration in which the caster board has two wheels. In the first configuration, the rear platform section can be supported by two wheels laterally offset from a longitudinal axis of the caster board. In the second configuration, the rear platform section can be supported by one wheel aligned with a longitudinal axis of the caster board. The rear platform section can include at least three mounting locations configured to have caster assemblies installed therein.

Abstract: A vehicle may include a pedal assembly, a motor assembly, and a drive unit that may be used to allow selective usage of one or both of the pedal assembly and the motor assembly to convey power to a driven wheel of the vehicle. The drive unit can include a gearbox that may enclose components which form at least part of a first power path between the pedal assembly and the driven wheel and a second power path between the motor assembly and the driven wheel. The first and second power paths can converge at a component within the gearbox. One-way bearings at points in the first and second power paths prior to the convergence of the power paths can inhibit or prevent the pedal assembly from being affected by operation of the motor assembly, and vice versa.

Abstract: Various personal mobility vehicles, such as scooters, are disclosed. The scooter can include at least one battery and motor for powering at least one driven wheel. The vehicle can include a gear assembly to convert a torque produced by the motor to a different torque to a driven shaft to power the at least one driven wheel. The battery can be removable.

Abstract: Various hub motor arrangements, systems, and methods are disclosed. The hub motor arrangement may include a transmission assembly to provide increased torque. The transmission assembly may include a motor gear, a planetary gear, an idler gear, and a ring gear. The idler gear may be positioned farther away from an axis of rotation of the hub motor arrangement compared to the planetary gear. The motor gear may drive the planetary gear, the planetary gear may drive the idler gear, and idler gear may drive the ring gear. The rotation of the ring gear may rotate a housing of the hub motor arrangement to propel a vehicle incorporating the hub motor arrangement.

Abstract: A method includes obtaining road patch type data associated with at least one road patch type, deriving, from the road patch type data, a set of road patch type parameters for the at least one road patch type, generating, based on the set of road patch type parameters, a set of risk metrics, each risk metric of the set of risk metrics corresponding to a respective road patch type parameter of the set of road patch type parameters, identifying, based at least in part on the set of risk metrics, a set of autonomous vehicle (AV) motion planning constraints selected for the at least one road patch type, and providing the set of AV motion planning constraints to update motion planning functionality performed by at least one component of an AV.

Abstract: Systems and methods for generating and displaying groupings of content recommendations using personas are provided. The system determines content for each of the plurality of personas. The determined content for each of the plurality of personas comprises content that shares a common genre or theme for each persona. The system populates each of the plurality of personas using the determined content for each of the plurality of personas. The system then causes display of at least some of the plurality of personas on a viewing device of a user. The at least some of the plurality of personas is selected for the user based on device data corresponding to the user, whereby the device data indicates user preferences and interactions with previous content.

Abstract: An interactive system can utilize microtechnology (e.g., a micro-electromechanical system (MEMS)), such as miniaturized microphone (e.g., a bone-conducting microphone), audio output device, microprocessor, and signal conversion and propagation means to create a personal area network (PAN) for a user. The system can include a voice input device (e.g., worn on one or more teeth of the user) that outputs a near-field magnetic induction (NFMI) signal based on a whisper input by the user. The NFMI signal is either detected by the user's mobile device, or converted into a wireless signal (e.g., a Bluetooth RF signal) detectable by the user's mobile device, for receiving voice commands (e.g., to provide personal assistant services) via a designated application running on the mobile device.