Abstract: One or more techniques for optimizing cancer classification based on covariate characteristics is disclosed. In a first approach, an analytics system may determine separate cutoff thresholds for positively detecting disease signal for different labels for a covariate characteristic. The system may subdivide training samples based on their labels for the covariate characteristic, to separately determine the cutoff thresholds. In other approaches, the system may train disparate classifiers for each population. The system separates the training samples based on their labels for the covariate characteristic, and separately trains classifiers to generate a signal vector representing an amount of disease signal detected in a sample. The classifiers may be trained on different feature sets as determined based on mutual information gain, genomic region coverage, and healthy activation fraction.

Abstract: In some embodiments, a computer-implemented method comprises: generating a group of customized products comprising one or more customized products, each customized product associated with a product type of a plurality of product types, each product type of the plurality of product types associated with a manufacturing constraint of multiple manufacturing constraints, each customized product having shared content that all customized products share; for a customized product from the group: obtaining a manufacturing method for manufacturing the customized product, determining a product type of the customized product and a manufacturing constraint associated with the product type, and determining physical constraints for manufacturing the customized product; generating transformed shared content to satisfy the physical constraints for manufacturing the customized product; in response to receiving a user input: automatically generating a GUI based on, at least in part, the shared content; using the GUI, generating

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: A packaged electronic device includes first conductive leads and second conductive leads at least partially exposed to an exterior of a package structure, and a multilevel lamination structure in the package structure. The multilevel lamination structure includes a first patterned conductive feature having multiple turns in a first level to form a first winding coupled to at least one of the first conductive leads in a first circuit, a second patterned conductive feature having multiple turns in a different level to form a second winding coupled to at least one of the second conductive leads in a second circuit isolated from the first circuit, and a conductive shield trace having multiple turns in a second level spaced apart from and between the first patterned conductive feature and the second patterned conductive feature, the conductive shield trace coupled in the first circuit.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: In some embodiments, a computer-implemented method comprises: generating a group of customized products comprising one or more customized products, each customized product associated with a product type of a plurality of product types, each product type of the plurality of product types associated with a manufacturing constraint of multiple manufacturing constraints, each customized product having shared content that all customized products share; for a customized product from the group: obtaining a manufacturing method for manufacturing the customized product, determining a product type of the customized product and a manufacturing constraint associated with the product type, and determining physical constraints for manufacturing the customized product; generating transformed shared content to satisfy the physical constraints for manufacturing the customized product; in response to receiving a user input: automatically generating a GUI based on, at least in part, the shared content; using the GUI, generating

Abstract: A heating device for heating fluids, such as water or a liquid coolant, for application in electric or hybrid vehicles, where the absence of an internal combustion engine or its shorter time of use requires using heating devices for heating either the passenger compartment or other parts of the vehicle that require it. The heating device is provided with a configuration which limits the temperature to the temperature at which heat exchange occurs between the heat generation source and the liquid to be heated, such that the liquid does not generate precipitates, prolonging the service life of the device.

Abstract: A continuous-flow heater is described, with a housing made from an aluminium-based alloy, in which a flow channel for a fluid to be heated extends from an inlet to an outlet, and a heating plate which is arranged in the housing, with a substrate made from steel, which carries heating conductor tracks, a frame embedded in a wall of the housing, wherein the heating plate forms one wall of the flow channel in the housing, and is welded to the frame.

Abstract: Computer-based models can be developed, deployed, and managed in an automated manner. For example, a model building tool can be selected based on the model building tool being compatible with one or more parameters. A first machine-learning model can be generated using the model building tool and trained using a training dataset. The first machine-learning model can then be used to perform a task. Thereafter, a new model-building tool can be selected based on the new model-building tool being compatible with the one or more parameters. A second machine-learning model can be generated using the new model-building tool and trained using the training dataset. The accuracy of the first machine-learning model can be compared to the accuracy of the second machine-learning model. Based on the second machine-learning model being more accurate, the second machine-learning model can be used to perform the particular task rather than the first machine-learning model.

Abstract: A continuous-flow heater is described, with a housing made from an aluminium-based alloy, in which a flow channel for a fluid to be heated extends from an inlet to an outlet, and a heating plate which is arranged in the housing, with a substrate made from steel, which carries heating conductor tracks, a frame embedded in a wall of the housing, wherein the heating plate forms one wall of the flow channel in the housing, and is welded to the frame.

Abstract: Computer-based models can be developed, deployed, and managed in an automated manner. For example, a model building tool can be selected based on the model building tool being compatible with one or more parameters. A first machine-learning model can be generated using the model building tool and trained using a training dataset. The first machine-learning model can then be used to perform a task. Thereafter, a new model-building tool can be selected based on the new model-building tool being compatible with the one or more parameters. A second machine-learning model can be generated using the new model-building tool and trained using the training dataset. The accuracy of the first machine-learning model can be compared to the accuracy of the second machine-learning model. Based on the second machine-learning model being more accurate, the second machine-learning model can be used to perform the particular task rather than the first machine-learning model.

Abstract: Computer-based models can be developed, deployed, and managed in an automated manner. For example, a model building tool can be selected based on the model building tool being compatible with one or more parameters. A first machine-learning model can be generated using the model building tool and trained using a training dataset. The first machine-learning model can then be used to perform a task. Thereafter, a new model-building tool can be selected based on the new model-building tool being compatible with the one or more parameters. A second machine-learning model can be generated using the new model-building tool and trained using the training dataset. The accuracy of the first machine-learning model can be compared to the accuracy of the second machine-learning model. Based on the second machine-learning model being more accurate, the second machine-learning model can be used to perform the particular task rather than the first machine-learning model.

Abstract: The present invention relates to a heating device for heating fluids, such as water or a liquid coolant, for example, which can be applied in electric or hybrid vehicles, for example, where the absence of an internal combustion engine or its shorter time of use requires using heating devices for heating either the passenger compartment or other parts of the vehicle that require it. The present invention is characterized by a configuration which limits the temperature to the temperature at which heat exchange occurs between the heat generation source and the liquid to be heated, such that the liquid does not generate precipitates, prolonging the service life of the device.

Abstract: Computer-based models can be developed, deployed, and managed in an automated manner. For example, a model building tool can be selected based on the model building tool being compatible with one or more parameters. A first machine-learning model can be generated using the model building tool and trained using a training dataset. The first machine-learning model can then be used to perform a task. Thereafter, a new model-building tool can be selected based on the new model-building tool being compatible with the one or more parameters. A second machine-learning model can be generated using the new model-building tool and trained using the training dataset. The accuracy of the first machine-learning model can be compared to the accuracy of the second machine-learning model. Based on the second machine-learning model being more accurate, the second machine-learning model can be used to perform the particular task rather than the first machine-learning model.

Abstract: Computer-implemented systems and methods for updating champion predictive models that operate within a production environment. A system and method can include evaluating the predictive model performance of a champion predictive model. Based upon an indication of decay of predictive model performance of the champion predictive model, a corrective action is performed to correct the performance of the champion predictive model.

Abstract: A DFH (Dynamic Flying Height) type slider ABS design has a stable flying height and a DFH efficiency that is uniform across the entire disk surface. These properties are a result of embedding the read/write head and heater in a trapezoidally bridged micro-pad having a very small surface area. The micro-pad is surrounded by a wing-like structure that projects from a central rail in the ABS and the micro pad is connected to an inner edge of that structure by a bridge having a trapezoidal shape. The trapezoidal shape responds effectively to variations in air flow direction and pressure point as the slider moves across the disk surface and, as a result, provides the uniform DFH efficiency. At the same time, the projecting wings and adjacent topology help to direct the airflow around the micro-pad and provide the stable flying height.