Abstract: The invention relates inter alia to methods of producing sulfated oligosaccharide derivatives and intermediates thereof. The sulfated oligosaccharide derivatives may be represented by the following formula (I): [X]nY?ZR1R2Formula (I) wherein: X and Y are any D- or L-hexose or pentose, wherein each hydroxyl group not involved in a glycosidic linkage is substituted by a group W, and Y has an anomeric carbon atom; W is SO3M, and M is any pharmaceutically acceptable cation; n is an integer from 2 to 6; Z is O, and is linked to the anomeric carbon atom of Y; and R1R2 together form a lipophilic moiety.

Abstract: A product unpacking system includes a work surface at a first height and a product unloading position at a second height. An adjustable cutter is positioned adjacent to the work surface and configured to cut a plurality of sides of each case. A case movement device, such as a robot or manual mover, is configured to retrieve a case from a group of cases and move the case to the cutter to cut a plurality of sides of the case. The case movement device may then move the cut case to an unload position over a product container to allow products within the case to drop into the product container. A system of conveyors may be used to convey empty product containers toward the work surface and to convey filled product containers away from the work surface. The system may be automated to receive recipe information for each case to be unloaded and modify parameters of the system based on the case.

Abstract: A system and method for unpacking a case are provided. The system may comprise a work surface that defines a cutting, extraction, and unloading position and a robot configured to move the cases between the respective positions. The robot may first engage and position the case in the cutting position, wherein a plurality of cutting arms cut a first pair of sides simultaneously near the case bottom. The robot rotates the case and the cutting arms cut another pair of sides simultaneously near the case bottom. The robot then moves the case from the cutting position to the extraction position, where the case bottom is retained and removed from the case. The robot then moves the bottomless case from the extraction position to the unloading position adjacent to the work surface, wherein the product inside the case is deposited into a receptacle through the open case bottom.

Abstract: A product unpacking system includes a work surface at a first height and a product unloading position at a second height. An adjustable cutter is positioned adjacent to the work surface and configured to cut a plurality of sides of each case. A case movement device, such as a robot or manual mover, is configured to retrieve a case from a group of cases and move the case to the cutter to cut a plurality of sides of the case. The case movement device may then move the cut case to an unload position over a product container to allow products within the case to drop into the product container. A system of conveyors may be used to convey empty product containers toward the work surface and to convey filled product containers away from the work surface. The system may be automated to receive recipe information for each case to be unloaded and modify parameters of the system based on the case.

Abstract: A process for preparing a compound of formula (I) wherein the process is suitable for large scale synthesis. The process includes the consecutive steps of a) reacting a compound of formula IX and a catalyst and optionally adding a base in an organic solvent and optional adding a basic fluoride source agent under suitable conditions to obtain a compound of formula X and b) removing the protective groups of the compound X to obtain the compound formula (I).

Abstract: A product unpacking system includes a work surface at a first height and a product unloading position at a second height. An adjustable cutter is positioned adjacent to the work surface and configured to cut a plurality of sides of each case. A case movement device, such as a robot or manual mover, is configured to retrieve a case from a group of cases and move the case to the cutter to cut a plurality of sides of the case. The case movement device may then move the cut case to an unload position over a product container to allow products within the case to drop into the product container. A system of conveyors may be used to convey empty product containers toward the work surface and to convey filled product containers away from the work surface. The system may be automated to receive recipe information for each case to be unloaded and modify parameters of the system based on the case.

Abstract: The present invention relates to a process for preparing a compound of formula (I) wherein said process is suitable for large scale synthesis.

Abstract: A product unpacking system includes a work surface at a first height and a product unloading position at a second height. An adjustable cutter is positioned adjacent to the work surface and configured to cut a plurality of sides of each case. A case movement device, such as a robot or manual mover, is configured to retrieve a case from a group of cases and move the case to the cutter to cut a plurality of sides of the case. The case movement device may then move the cut case to an unload position over a product container to allow products within the case to drop into the product container. A system of conveyors may be used to convey empty product containers toward the work surface and to convey filled product containers away from the work surface. The system may be automated to receive recipe information for each case to be unloaded and modify parameters of the system based on the case.

Abstract: Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d] oxazole useful in the treatment of Duchenne muscular dystrophy.

Abstract: Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d]oxazole useful in the treatment of Duchenne muscular dystrophy.

Abstract: A process for the preparation of L-gluconic acid or a salt thereof, comprises treating an aqueous solution of 6-bromo-6-deoxy-2,3-anhydro-D-manno-1,4-lactone with a base at a pH of at least 12 and at a temperature of 45 to 55° C. to obtain an aqueous solution of L-gluconic acid.

Abstract: A wheat variety designated XW03U, the plants and seeds of wheat variety XW03U, methods for producing a wheat plant produced by crossing the variety XW03U with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety XW03U with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety XW03U. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety XW03U and to wheat varieties or breeding lines produced by those methods.

Abstract: A wheat variety designated XW03X, the plants and seeds of wheat variety XW03X, methods for producing a wheat plant produced by crossing the variety XW03X with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety XW03X with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety XW03X. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety XW03X and to wheat varieties or breeding lines produced by those methods.

Abstract: A wheat variety designated XW03R, the plants and seeds of wheat variety XW03R, methods for producing a wheat plant produced by crossing the variety XW03R with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety XW03R with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety XW03R. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety XW03R and to wheat varieties or breeding lines produced by those methods.