Abstract: The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.

Abstract: A microfluidic sealing valve 1 comprises a primary channel 2, a valve channel 4, and a geometry that permits liquid in the primary channel 2 to flow into the valve channel 4 through an inlet 5. Liquid in the primary channel 2 is inhibited from flowing through a first port 8 into the void volume 7. A meniscus 9 moved by a flow of liquid in the primary channel 2 is restrained at the first port 8. A flow of liquid through the primary channel 2 generates a capillary force that causes the flow of liquid to flow into the valve channel 4. A capillary force generated by the flow of liquid through the valve channel 4 causes the meniscus 9 to expand from the first port 8 into the primary channel, to inhibit flow of liquid in the primary channel 2 past the first port 8.

Abstract: Radiation shielding glass articles with thin glass faceplates that improve transmission are disclosed. A radiation shielding glass article includes a radiation shielding glass having a first surface and an opposing second surface; and a first thin glass faceplate having a first surface and an opposing second surface, wherein one of said first surface or second surface of said first thin glass faceplate faces the first surface of the radiation shielding glass, wherein the first thin glass faceplate having a thickness of less than or equal to 1.0 mm is bonded to the first surface of the radiation shielding glass, and wherein the first thin glass faceplate is one of an alkaline boro-aluminosilicate glass, or a chemically strengthenable sodium aluminum silicate glass.

Abstract: Embodiments of systems and methods that can facilitate data collection for valve diagnostics. The systems can include a valve assembly with a valve and a sampling device that is configured to access a repository with a first buffer and a second buffer. During operation, the valve assembly is configured to read data representing operating variables for the valve into the first buffer. The valve assembly is also configure to determine a quality measure for a first sample set of data from the first buffer, the quality measure indicating the usefulness of the first sample set of data for predicting performance of the valve relative to a second sample set of data from the second buffer. In one embodiment, the valve assembly is further configured to read data from the first buffer into the second buffer in response to the quality measure indicating that the first sample set of data is relatively more useful than the second sample set of data.

Abstract: A method to detect cycling of components that result from use of a tight shut-off mode on a valve assembly. Embodiments of the method use operating data from the valve assembly. This operating data includes data that reflects a position for the closure member relative to the seat. This position often corresponds with a measured position of one or more components (e.g., the valve stem) on the valve assembly. In one embodiment, the method includes steps for comparing the measured position to a boundary criteria that defines one or more boundary values proximate, and often equal to, the threshold levels of the tight shut-off mode. The method can also includes steps for identifying patterns in the data that indicate that the closure member is cycling from its closed position to a second position due to tight shut-off mode.

Abstract: Embodiments of systems and methods that can facilitate data collection for valve diagnostics. The systems can include a valve assembly with a valve and a sampling device that is configured to access a repository with a first buffer and a second buffer. During operation, the valve assembly is configured to read data representing operating variables for the valve into the first buffer. The valve assembly is also configure to determine a quality measure for a first sample set of data from the first buffer, the quality measure indicating the usefulness of the first sample set of data for predicting performance of the valve relative to a second sample set of data from the second buffer. In one embodiment, the valve assembly is further configured to read data from the first buffer into the second buffer in response to the quality measure indicating that the first sample set of data is relatively more useful than the second sample set of data.

Abstract: A method of performing online diagnostics for a valve includes receiving valve information while the valve is in operation. The valve information includes setpoint data and position data associated with the valve. The method further includes processing the setpoint data and the position data at a plurality of time intervals, and detecting an occurrence of a stick-slip based on the processing.

Abstract: Embodiments of a method and a system, which is configured to implement the method, to process data from one or more valve assemblies found e.g., on a process line. These embodiments can generate a listing that identifies how network/system bandwidth is allocated for the collection of data from the valve assemblies. The embodiments can also process the data to re-arrange the valve assemblies in the listing to better allocate the network/system bandwidth to certain ones of the valve assemblies that require more data to properly assess the operation of the valve assembly. In this way, further diagnostics using the data can identify any changes in operation of the valve assemblies that might be detrimental to the valve assembly and/or the process line in general.

Abstract: Embodiments of systems and methods that can facilitate data collection for valve diagnostics. The systems can include a valve assembly with a valve and a sampling device that is configured to access a repository with a first buffer and a second buffer. During operation, the valve assembly is configured to read data representing operating variables for the valve into the first buffer. The valve assembly is also configure to determine a quality measure for a first sample set of data from the first buffer, the quality measure indicating the usefulness of the first sample set of data for predicting performance of the valve relative to a second sample set of data from the second buffer. In one embodiment, the valve assembly is further configured to read data from the first buffer into the second buffer in response to the quality measure indicating that the first sample set of data is relatively more useful than the second sample set of data.

Abstract: A method to detect cycling of components that result from use of a tight shut-off mode on a valve assembly. Embodiments of the method use operating data from the valve assembly. This operating data includes data that reflects a position for the closure member relative to the seat. This position often corresponds with a measured position of one or more components (e.g., the valve stem) on the valve assembly. In one embodiment, the method includes steps for comparing the measured position to a boundary criteria that defines one or more boundary values proximate, and often equal to, the threshold levels of the tight shut-off mode. The method can also includes steps for identifying patterns in the data that indicate that the closure member is cycling from its closed position to a second position due to tight shut-off mode.

Abstract: A method to detect cycling of components that result from use of a tight shut-off mode on a valve assembly. Embodiments of the method use operating data from the valve assembly. This operating data includes data that reflects a position for the closure member relative to the seat. This position often corresponds with a measured position of one or more components (e.g., the valve stem) on the valve assembly. In one embodiment, the method includes steps for comparing the measured position to a boundary criteria that defines one or more boundary values proximate, and often equal to, the threshold levels of the tight shut-off mode. The method can also includes steps for identifying patterns in the data that indicate that the closure member is cycling from its closed position to a second position due to tight shut-off mode.

Abstract: A computer-implemented method for monitoring characteristic data includes selecting a first operable system device and receiving a first plurality of data from the first operable system device. The first plurality of data represents at least one characteristic of the first operable system device at a first plurality of points in time. The method also includes determining whether the first plurality of data is useful. If the data is useful, the method also includes receiving a second plurality of data from the first operable system device, the second plurality of data represents at least one characteristic of the first operable system device at a second plurality of points in time, wherein the second plurality of points in time is substantially larger than the first plurality of points in time. If the data is not useful, the method further includes selecting a second operable system device.

Abstract: A method to detect cycling of components that result from use of a tight shut-off mode on a valve assembly. Embodiments of the method use operating data from the valve assembly. This operating data includes data that reflects a position for the closure member relative to the seat. This position often corresponds with a measured position of one or more components (e.g., the valve stem) on the valve assembly. In one embodiment, the method includes steps for comparing the measured position to a boundary criteria that defines one or more boundary values proximate, and often equal to, the threshold levels of the tight shut-off mode. The method can also includes steps for identifying patterns in the data that indicate that the closure member is cycling from its closed position to a second position due to tight shut-off mode.

Abstract: A method of performing online diagnostics for a valve includes receiving valve information while the valve is in operation. The valve information includes setpoint data and position data associated with the valve. The method further includes processing the setpoint data and the position data at a plurality of time intervals, and detecting an occurrence of a stick-slip based on the processing.

Abstract: A computer-implemented method for monitoring characteristic data includes selecting a first operable system device and receiving a first plurality of data from the first operable system device. The first plurality of data represents at least one characteristic of the first operable system device at a first plurality of points in time. The method also includes determining whether the first plurality of data is useful. If the data is useful, the method also includes receiving a second plurality of data from the first operable system device, the second plurality of data represents at least one characteristic of the first operable system device at a second plurality of points in time, wherein the second plurality of points in time is substantially larger than the first plurality of points in time. If the data is not useful, the method further includes selecting a second operable system device.

Abstract: Embodiments of systems and methods that can facilitate data collection for valve diagnostics. The systems can include a valve assembly with a valve and a sampling device that is configured to access a repository with a first buffer and a second buffer. During operation, the valve assembly is configured to read data representing operating variables for the valve into the first buffer. The valve assembly is also configure to determine a quality measure for a first sample set of data from the first buffer, the quality measure indicating the usefulness of the first sample set of data for predicting performance of the valve relative to a second sample set of data from the second buffer. In one embodiment, the valve assembly is further configured to read data from the first buffer into the second buffer in response to the quality measure indicating that the first sample set of data is relatively more useful than the second sample set of data.

Abstract: Embodiments of a method and a system, which is configured to implement the method, to process data from one or more valve assemblies found e.g., on a process line. These embodiments can generate a listing that identifies how network/system bandwidth is allocated for the collection of data from the valve assemblies. The embodiments can also process the data to re-arrange the valve assemblies in the listing to better allocate the network/system bandwidth to certain ones of the valve assemblies that require more data to properly assess the operation of the valve assembly. In this way, further diagnostics using the data can identify any changes in operation of the valve assemblies that might be detrimental to the valve assembly and/or the process line in general.

Abstract: A system and method of synchronizing a routing system having an active subsystem actively processing within the routing system and a standby subsystem. The method includes the steps of specifying an address or range of addresses of data to be synchronized within the routing system, detecting a write to main memory of the active subsystem, and comparing an address of the detected write to main memory of the active subsystem with the specified address or range of addresses. Next, the address and data of the detected write to main memory are stored in a First In First Out (FIFO) queue of the active subsystem if the address of the detected write to main memory matches the specified address or range of addresses. The address and data of the detected write to main memory are sent to the standby subsystem where the data and address are written to the main memory of the standby subsystem.