Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.

Abstract: A system to limit the expression of a vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing overexpression toxicity is described. This provides for ‘dosage-insensitivity’, whereby cells or tissues receiving more vector-derived transgene are disproportionately suppressed through an in-built single gene circuit that can regulate adaptively.

Abstract: MeCP2 based therapy. The present invention relates to synthetic polypeptides that are useful in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome. The present invention provides synthetic polypeptides comprising: i) an MBD amino acid sequence showing at least 70% similarity with the amino acid sequence showing at least 70% similarity with the amino acid sequence as depicted in SEQ ID NO: 2, wherein the polypeptide has a deletion of at least 50 amino acids, when compared to the full length MeCP2 e1 and e2 sequences. The invention further provides nucleic acid constructs, expression vectors, virions, pharmaceutical compositions, and cells providing polynucleotides of the invention. The invention further provides methods of treating or preventing disease in an animal comprising administering to said animal a synthetic polypeptide according to the invention.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a collective address book system. One of the methods includes: receiving a request from a user to contact a person of interest; determining that contact information for the person of interest is not available in the user's contact information to which the system has access; determining that the collective address book system has access to contact information for the person of interest; generating proxy contact data for the person of interest; and providing the proxy contact data to the first user.

Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a collective address book system. One of the methods includes: receiving a request from a user to contact a person of interest; determining that contact information for the person of interest is not available in the user's contact information to which the system has access; determining that the collective address book system has access to contact information for the person of interest; generating proxy contact data for the person of interest; and providing the proxy contact data to the first user.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a collective address book system. One of the methods includes: receiving a request from a user to contact a person of interest; determining that contact information for the person of interest is not available in the user's contact information to which the system has access; determining that the collective address book system has access to contact information for the person of interest; generating proxy contact data for the person of interest; and providing the proxy contact data to the first user.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for resolving inconsistencies in information graphs.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for identifying user-specific values for entity attributes. One of the methods includes maintaining data representing a particular cluster of a plurality of claims about a particular entity, wherein each claim is an assertion by a respective claimant about an attribute value of the particular entity; receiving a request for a value of a particular attribute of the particular entity that has been submitted by a requesting user; determining, from attribute values for the particular attribute identified by the claims in the particular cluster, a user-specific attribute value for the particular attribute value; and providing the user-specific attribute value in response to the request.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a collective address book system. One of the methods includes: receiving a request from a user to contact a person of interest; determining that contact information for the person of interest is not available in the user's contact information to which the system has access; determining that the collective address book system has access to contact information for the person of interest; generating proxy contact data for the person of interest; and providing the proxy contact data to the first user.

Abstract: A wireless computerized will call system is provided for filling prescriptions and then locating specific prescriptions that have been filled when the customer arrives to pick up the prescription. The system includes a computer workstation or network, a wireless transmitter, and hanger bags for temporarily storing prescriptions awaiting customer pick up. The hanger bags are equipped with wireless receivers and transducers. When a pharmacy worker commands the computer system to locate a specific prescription, the specific hanger bag containing that prescription receives a wireless signal from the computer system and activates the transducer on the hanger bag to alert the pharmacy worker to the location of the prescription.

Abstract: An energy management controller for controlling and limiting the time during which high current draws may be made by one or more of a plurality of single serve coffee brewers that are commonly connected to the same circuit and which include heater constructions that require and draw high power at certain times during operation, and require and draw lower power at other times. It includes one controller board, connected to the primary brewer to complete a circuit, and which board includes heat and wait timer functions to monitor the power status usage with respect to all of the brewers.

Abstract: A wireless computerized will call system is provided for filling prescriptions and then locating specific prescriptions that have been filled when the customer arrives to pick up the prescription. The system includes a computer workstation or network, a wireless transmitter, and hanger bags for temporarily storing prescriptions awaiting customer pick up. The hanger bags are equipped with wireless receivers and transducers. When a pharmacy worker commands the computer system to locate a specific prescription, the specific hanger bag containing that prescription receives a wireless signal from the computer system and activates the transducer on the hanger bag to alert the pharmacy worker to the location of the prescription.

Abstract: An energy management controller for controlling and limiting the time during which high current draws may be made by one or more of a plurality of single serve coffee brewers that are commonly connected to the same circuit and which include heater constructions that require and draw high power at certain times during operation, and require and draw lower power at other times. It includes one controller board, connected to the primary brewer to complete a circuit, and which board includes heat and wait timer functions to monitor the power status usage with respect to all of the brewers.

Abstract: The present invention relates to an automated system for pharmaceutical singulation, counting and dispensing, whereby a bulk of stored pharmaceutical units are singulated into a single file line for counting and dispensing. With reference to the drawings, the pharmaceutical singulation, counting and dispensing system comprises generally, a deck assembly (A), a cylindrical chamber (B), a rotatable transport ring (C), a plurality of adjustable fingers (D), an adjustable reciprocating member (E), an adjustable rotatable member (F), a counting system (G), a hopper (H), and a control system (I).

Abstract: A system for providing polymorphic image data for images in a graphical user interface on a computer system includes an operating system, and an imaging object structure, the imaging object structure included in the operating system and utilized to generate images in the graphical user interface. Additionally, the imaging object structure further comprises a subclass of imaging objects, the subclasses comprising singular imaging objects and composite imaging objects. The singular imaging objects further include, but are not limited to, text imaging objects, picture imaging objects, pattern imaging objects, and icon imaging objects. Additionally, the composite imaging objects generate composite images of a desired combination of singular images generated by the singular imaging objects. Further, the imaging object structure includes a SOM object structure.

Abstract: A system for providing polymorphic image data for images in a graphical user interface on a computer system includes an operating system, and an imaging object structure, the imaging object structure included in the operating system and utilized to generate images in the graphical user interface. Additionally, the imaging object structure further comprises a subclass of imaging objects, the subclasses includes singular imaging objects and composite imaging objects. The singular imaging objects further include, but are not limited to, text imaging objects, picture imaging objects, pattern imaging objects, and icon imaging objects. Additionally, the composite imaging objects generate composite images of a desired combination of singular images generated by the singular imaging objects. Further, the imaging object structure includes a SOM object structure.

Abstract: A transistor logic device uses a signal from a transducer responsive to the centrifugal force experienced in or near the strike zone of a baseball bat during the swing to digitally process and numerically display numerals representative of the maximum centrifugal force experienced during the swing. Knowledge of the maximum force during the swing is useful on a comparative basis in improving batting performance and the speed of the swing can be computed or the displayed numbers can be converted into numbers revealing swing speed in miles per hour or other units. The use of digital data, dealt with digitally, and displayed digitally simplifies, and reduces the cost and size of the apparatus to allow it to be integrated within an actual baseball bat.