Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Abstract: Embodiments are directed to managing content over a network. A plurality of events that may be associated with event sources may be determined. Action information may be generated based on classification of events to action events, such that the events may correspond to a campaign for a merchant. Classifying the events may also include, determining an action type that may correspond to each event based in part on an event source that corresponds to the events. Performance information may be generated based on the action information. Comparison information may be generated based on at least other performance information that may correspond to other campaigns that may be associated with other merchants. Recommendation information may be generated based on the performance information and the comparison information. Report information may be generated for display to a user based on the performance information and the recommendation information.

Abstract: Embodiments are directed to managing content over a network. Managed content may be provided to a client application. A widget controller may be arranged to determine locations that may be associated with a consumer based on information included in a consumer profile. The widget controller may enable the consumer to identify a hyper local region corresponding to the determined location that may be associated with the consumer. The widget controller may generate a request for content to a content delivery server based on the consumer's profile. Content corresponding to the request may be provided to the client application from the content delivery server. The widget controller may then deploy to the content to at least one widget. The widget controller may monitor the widgets to detect and track consumer actions with the widgets. The consumer actions may be communicated a content management server for further analysis.

Abstract: Embodiments are directed towards recommending coupon templates to a customer, from which the customer can select and have published to consumers. A ranked order may be determined for the coupon templates for each of a plurality of categories. A subset of the coupon templates may be recommended and provided to a customer. The subset of coupon templates may be determined based on a category of the customer, the ranked order of the plurality of coupon templates for the category, external variables, or the like, or any combination thereof. One or more of the subset of coupon templates may be selected by the customer and published to the consumers. The ranked order of the plurality of coupon templates may be determined and/or modified based on monitored actions associated with previously published coupons, such as by employing a success of similar attributes associated with previously published coupons.

Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.

Abstract: The invention provides non-immunostimulatory polynucleotide antigen conjugates and methods for treating unwanted immune reactions in individuals using the non-immunostimulatory polynucleotide antigen conjugates.

Abstract: A channel interface architecture for a time division multiplexed (TDM) data communication system has a plurality of TDM communication ports coupled to serial TDM communication channels. The channel interface architecture interfaces data from any channel of any TDM communication port with any TDM communication channel of any other TDM communication port, on a per time slot/channel basis. The architecture includes a parallel data bus portion, an address bus portion, and a control portion. Each of a plurality of TDM communication channel interface units, associated with the ports, includes a multipage memory that stores data received from an associated serial communication link. The memory also selectively stores data that has been asserted onto the data bus portion of the bus architecture from another interface unit.

Abstract: A channel interface architecture for a time division multiplexed (TDM) data communication system has a plurality of TDM communication ports coupled to serial TDM communication channels. The channel interface architecture interfaces data from any channel of any TDM communication port with any TDM communication channel of any other TDM communication port, on a per time slot/channel basis. The architecture includes a parallel data bus portion, an address bus portion, and a control portion. Each of a plurality of TDM communication channel interface units, associated with the ports, includes a multipage memory that stores data received from an associated serial communication link. The memory also selectively stores data that has been asserted onto the data bus portion of the bus architecture from another interface unit.

Abstract: The invention provides in vivo methods for potentiating IL-10 mediated inhibition of cytokine production by T cells in a mammal. The method comprises co-administering to the mammal an effective amount of IL-4 and IL-10, preferably intravascularly.