Patents by Inventor Robert Comgall Ewins

Robert Comgall Ewins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparaing (E)-methyl 2-[2-(6-(2-cyanophenoxy)-pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate in the absence of copper(salt) and of N,N-dimethylformamide
    Patent number: 6153750
    Abstract: A process for preparing (E)-methyl 2-[2-(6-(-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate comprising contacting (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate or methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropanoate with 2-cyanophenate anions, the process being conducted in the absence of copper or a copper salt and in the absence of N,N-dimethylformamide. The 2-cyanophenate anions are generated in situ by reacting 2-cyanophenol with an alkali metal carbonate.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: November 28, 2000
    Assignee: ZENECA Limited
    Inventors: Alan John Whitton, Ian George Fleming, Robert Comgall Ewins, Raymond Vincent Heavon Jones, Samuel McNeish