Abstract: A building system is disclosed comprising a beam and column connection particularly suited for mass timber buildings. A first connection arrangement comprises a projection and slot arrangement with the beam being supported on an upwardly facing bearing surface. A second connection arrangement may be provided to tie the column to the beam. The system also discloses arrangements to accommodate greater tolerance at the connection and to provide an ability to accommodate limited rotation under dynamic loading.

Abstract: A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation Endproducts (RAGE) linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described.

Abstract: A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation End (RAGE) products linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described and claimed.

Abstract: A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation End (RAGE) products linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described and claimed.

Abstract: This invention relates to the detection of human biovibrations using a digital signal processing (DSP) actigraph worn by the individual, and in at least one method using any noise existing in the signals. Human biovibrations result from the human body having reverberations and oscillations from bodily functioning. The DSP actigraph has been shown to be able to identify heart beat and breathing of an individual. The invention includes a method comprising: recording movement data of an individual that includes biovibrations data, determining when the movement data substantially falls within a predetermined threshold representative of death, and providing a notification. The invention in at least one embodiment includes a method comprising: monitoring activity counts for zero crossing mode, above threshold mode, and proportional integrative mode, providing a notification when all three activity counts are within a respective predetermined range for a period of time.

Abstract: This invention relates to the detection of human biovibrations using a digital signal processing (DSP) actigraph worn by the individual, and in at least one method using any noise existing in the signals. Human biovibrations result from the human body having reverberations and oscillations from bodily functioning. The DSP actigraph has been shown to be able to identify heart beat and breathing of an individual. The invention includes a method comprising: recording movement data of an individual that includes biovibrations data, determining when the movement data substantially falls within a predetermined threshold representative of death, and providing a notification. The invention in at least one embodiment includes a method comprising: monitoring activity counts for zero crossing mode, above threshold mode, and proportional integrative mode, providing a notification when all three activity counts are within a respective predetermined range for a period of time.