Abstract: Provided herein are combination dosing regimens comprising administering an antibody-drug conjugate (ADC) and a hyaluronidase. In embodiments, the hyaluronidase is a soluble hyaluronidase. In embodiments, the ADC and hyaluronidase are administered subcutaneously. Pharmaceutical compositions comprising an ADC and a hyaluronidase are also provided. In embodiments, the dosing regimens and the pharmaceutical compositions are used in a method of treating or preventing cancer, a cardiometabolic disease/disorder, an inflammatory disease/disorder, or an autoimmune disease/disorder in a patient in need thereof.

Abstract: Provided are combination dosing regimens comprising administering an antibody-drug conjugate and hyaluronidase. Combinations and compositions containing the antibody-drug conjugate and hyaluronidase are provided. The dosing regimens and combinations are for treating or preventing cancer.

Abstract: An outer belt molding for a vehicle includes a body portion having a first end and a second end. A cap is disposed at the first end of the body portion, and an anti-rattle bumper is disposed at the second end of the body portion. A window sealing arm is compliantly coupled to the body portion at a location between the cap and the anti-rattle bumper, and forms an acute angle with the first end of the body portion. Additionally, a body sealing arm is compliantly coupled to the window sealing arm and extends toward the body portion.

Abstract: The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The compounds, compositions and methods are useful for introducing agents such as genes into individual cells, as well as cells that are present as a tissue or organ.

Abstract: The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The compounds, compositions and methods are useful for introducing agents such as genes into individual cells, as well as cells that are present as a tissue or organ.

Abstract: This invention proposes devices and methods directed to providing rapid and complete surgical removal of the nucleus from the spine intervertebral space. In addition, the invention protects the endplate tissue of vertebrae containing the disc and limits damage to the integrity of the disc annulus.

Abstract: The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The compounds, compositions and methods are useful for introducing agents such as genes into individual cells, as well as cells that are present as a tissue or organ.

Abstract: Methods and pharmaceutical compositions for administering protein or gene therapy to tissues or organs having an epithelial cell layer are provided. A protein or nucleic acid encoding the protein is administered to the target tissue or organ in combination with treatment with a delivery enhancing agent which increases the delivery of the interferon or nucleic acid to the cells of the target tissues or organs. The methods and combinations are particularly useful in the treatment of cancers and other conditions responsive to interferon therapy. An exemplary method comprises the transurethral intravesical administration to the bladder of a therapeutically effective amount of a pharmaceutical composition comprising an alpha-interferon or a gene delivery system encoding the interferon and SYN3 or a SYN3 homolog or analog.