Patents by Inventor Robert Copeland

Robert Copeland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAYS AND PEPTIDE SUBSTRATE FOR DETERMINING AGGRECAN DEGRADING METALLO PROTEASE ACTIVITY
    Publication number: 20070238136
    Abstract: This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.
    Type: Application
    Filed: April 10, 2007
    Publication date: October 11, 2007
    Inventors: Jeffrey Miller, Elizabeth Arner, Robert Copeland, Gary Davis, Ruiqin Liu, Michael Pratta, Micky Tortorella
  • Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
    Publication number: 20070149763
    Abstract: The present invention provides the crystal structure of BACE-1 complexed with both an active site inhibitor and an exosite peptide containing the core sequence YPYFI. The crystal structure shows the exosite peptide bound to the BACE-1 exosite and identifies a novel peptide binding site on the surface of the BACE-1. The invention also provides the residues that make up the exosite binding site within 6.0 ? of any exosite peptide atom which are: E316, K317, F318, P319, F322, G325, E326, Q327, L328, V329, C330, W331, Q332, A333, T335, D372, V373, A374, S376, D378, D379, C380, Y381.
    Type: Application
    Filed: January 3, 2007
    Publication date: June 28, 2007
    Inventors: Michael Kornacker, Robert Copeland, Joseph Hendrick, Zhihong Lai, Claudio Mapelli, Mark Witmer, Jovita Marcinkeviciene, William Metzler, Ving Lee, Douglas Riexinger, Jody Muckelbauer, Chiehying Chang, Daniel Camac, Paul Morin