Abstract: Provided herein are methods of treating and/or preventing cancer drug resistance using antagonists of KDM5.

Abstract: The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B (also called FoxM1) activity in a tumor cell. The invention also provides FoxM1B siRNA molecules and pharmaceutical compositions comprising FoxM1B siRNA molecules, wherein the siRNA molecules can inhibit FoxM1B activity and can inhibit proliferation of tumor cells. The invention further provides methods for preventing tumor growth, progression or both in an animal comprising inhibiting FoxM1B activity using siRNA molecules or pharmaceutical compositions comprising FoxM1B siRNA molecules.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A document management system is provided for integrating documents generated in an enterprise into an enterprise data store where the documents can be accessed later. Documents in a first format and a specification containing instructions for describing the documents are provided. The documents are received in a second format, along with descriptions of the documents. The documents in the second format are imported into the data store responsive to the descriptions so that they may be located easily. Beneficially, the invention provides simpler and more flexible conversion and indexing processes for users seeking to electronically store and access documents after their creation.

Abstract: A joint stabilizing apparatus having an expandable cylindrical housing is inserted into a circular hole drilled at a “loose joint” of a concrete slab that is to be stabilized against relative vertical displacement between adjacent slab sections. The hole is drilled downward into the concrete, centered on the plane of a lateral opening/joint in the concrete slab. The expandable housing comprises two rigid semi-circular housing halves, and the assembly is oriented inside of the circular hole such that the two housing halves are on opposite sides of the centerline of the lateral opening/joint. The housing halves are pushed apart by turning of a threaded bolt inside of the housing. Turning of the bolt causes two bi-laterally symmetric wedge blocks to draw towards each other, and pressing the bearing surfaces of the wedge blocks against inclined surfaces inside of the respective housing halves.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A dispenser of single-use portions of preparations for beverages, comprising a structure that supports at least one storage assembly for single-use portions provided with a discharge outlet for the discharge of the portions, at least one distribution assembly for the portions which is provided with an outlet for dispensing said portions and with a device for transferring the portions from the discharge outlet to the dispensing outlet, which are interposed between the storage assembly and the distribution assembly.

Abstract: A system (20) for generating tasks related to electronic image files. System (20) includes an electronic document manager (EDM) (22) that is in communication with a task engine (24). EDM (22) receives electronic image file (EIF) batches (26) generated by a scanning device application (28) and scanning device (30) and third-party generated EIF batches (32). As discussed further below, EDM (22) shares information derived from EIF batches (26) and (32) with task engine (24). In turn, task engine (24) generates EIF-related tasks. Another aspect is a method (170) that sorts or filters the electronic image files stored in EIF database (80) and returns either a list or images of the sorted or filtered files to first portion (120) of graphical user interface (90) for display to a user. Another aspect is a method (180) of generating tasks related to electronic image files.

Abstract: A document management system is provided for integrating documents generated in an enterprise into an enterprise data store where the documents can be accessed later. Documents in a first format and a specification containing instructions for describing the documents are provided. The documents are received in a second format, along with descriptions of the documents. The documents in the second format are imported into the data store responsive to the descriptions so that they may be located easily. Beneficially, the invention provides simpler and more flexible conversion and indexing processes for users seeking to electronically store and access documents after their creation.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A dispenser of single-use portions of preparations for beverages, comprising a structure that supports at least one storage assembly for single-use portions provided with a discharge outlet for the discharge of the portions, at least one distribution assembly for the portions which is provided with an outlet for dispensing said portions and with a device for transferring the portions from the discharge outlet to the dispensing outlet, which are interposed between the storage assembly and the distribution assembly.

Abstract: A flexible corrugated hose coupling apparatus is provided for coupling a corrugated hose to a cylindrical neck or sleeve. A resilient hollow cylindrical coupling member has two ends and a generally smooth interior and exterior cylindrical surface and has an annular coaxial bore extending into one end thereof and shaped for threadedly receiving a corrugated hose of a predetermined size to allow the flexible coupling member to be threaded onto the end of a flexible corrugated hose. A clamp can be extended around the resilient hollow cylindrical coupling member for clamping the coupling member and the hose threaded thereinto a coupling neck, such as the neck from a vehicle radiator, so that a flexible corrugated hose can be cut to any length and attach to a smooth or rigid neck with a clamp to achieve a fluid type seal between the corrugated hose and neck.