Patents by Inventor Robert Cottone

Robert Cottone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080097575
    Abstract: A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.
    Type: Application
    Filed: October 20, 2007
    Publication date: April 24, 2008
    Applicant: OrbusNeich Medical, Inc.
    Inventor: Robert Cottone
  • Publication number: 20080051873
    Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 28, 2008
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Shusheng Ye, John Pazienza
  • Publication number: 20080051875
    Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 28, 2008
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Shusheng Ye, John Pazienza
  • Publication number: 20080051868
    Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 28, 2008
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Shusheng Ye, John Pazienza
  • Publication number: 20080051874
    Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 28, 2008
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Shusheng Ye, John Pazienza
  • Publication number: 20070213801
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: September 13, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael John Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070196422
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: October 27, 2006
    Publication date: August 23, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070191932
    Abstract: Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells.
    Type: Application
    Filed: January 12, 2007
    Publication date: August 16, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070156232
    Abstract: This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fillerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of eadothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 5, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland
  • Publication number: 20070141107
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Application
    Filed: November 15, 2006
    Publication date: June 21, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Margaret Yoklavich
  • Publication number: 20070134290
    Abstract: A drug eluting medical device is provided for implanting into vessels or luminal structures within the body of a patient. The coated medical device, such as a stent, vascular, or synthetic graft comprises a coating consisting of a controlled-release matrix of a bioabsorbable, biocompatible, bioerodible, biodegradable, nontoxic material, such as a Poly(DL-Lactide-co-Glycolide) polymer, and at least one pharmaceutical substance, or bioactive agent incorporated within the matrix or layered within layers of matrix. In particular, the drug eluting medical device when implanted into a patient, delivers the drugs or bioactive agents within the matrix to adjacent tissues in a controlled and desired rate depending on the drug and site of implantation.
    Type: Application
    Filed: July 26, 2006
    Publication date: June 14, 2007
    Inventors: Stephen Rowland, Ike Juman, Robert Cottone, David Camp
  • Publication number: 20070128723
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Application
    Filed: November 15, 2006
    Publication date: June 7, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Stephen Rowland, Sherry Parker
  • Publication number: 20070129789
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 7, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Stephen Rowland, Sherry Parker
  • Publication number: 20070123977
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Application
    Filed: November 15, 2006
    Publication date: May 31, 2007
    Applicant: OrbusNeich Medical, Inc.
    Inventors: Robert Cottone, Margaret Yoklavich, Sherry Parker
  • Publication number: 20070055367
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: June 9, 2006
    Publication date: March 8, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070042017
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: February 22, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20060135476
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 22, 2006
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20060121012
    Abstract: Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells.
    Type: Application
    Filed: April 29, 2005
    Publication date: June 8, 2006
    Applicant: ORBUS MEDICAL TECHNOLOGIES, INC.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland
  • Publication number: 20050271701
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Application
    Filed: March 10, 2005
    Publication date: December 8, 2005
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Robert Cottone, Stephen Rowland, Horace Davis, Michael Kutryk
  • Publication number: 20050025752
    Abstract: Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
    Type: Application
    Filed: April 30, 2004
    Publication date: February 3, 2005
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland