Patents by Inventor Robert Crombie
Robert Crombie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11912693Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.Type: GrantFiled: June 12, 2018Date of Patent: February 27, 2024Assignee: TREVENA, INC.Inventors: Philip Michael Pitis, Robert Eugene Boyd, Tamara Ann Miskowski Daubert, Michael John Hawkins, Guodong Liu, Aimee Crombie Speerschneider
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Patent number: 11912713Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.Type: GrantFiled: November 22, 2021Date of Patent: February 27, 2024Assignee: Trevena, Inc.Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero
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Publication number: 20220133722Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of symptoms associated with endocrine disturbances, such as hot flashes. The pharmaceutical compositions comprise a tricyclic amino containing compound of formula (I), such as MSX-122 (also known as “Q-122”) (N,N?-(1,4-phenylenebis(methylene))bis(pyrimidin-2-amine)), and one or more pharmaceutically acceptable excipients. The pharmaceutical compositions may be given in certain doses and/or dosing regimens, preferably twice daily.Type: ApplicationFiled: February 14, 2020Publication date: May 5, 2022Inventors: Robert Crombie, Ardian Latifi
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Patent number: 7442787Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE). The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: March 22, 2005Date of Patent: October 28, 2008Assignee: Millipore CorporationInventors: Michael Antoniou, Robert Crombie
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Publication number: 20060161968Abstract: Prototype software is securely delivered and evaluated by electronic transfer over a network. The software is secured by multiple levels of encryption to prevent unauthorized copying, modification, and/or use of the prototype software. Electronic transfer of the prototype software minimizes the time and cost associated with providing prototype software for testing to remote third party testers. Once the software has been transferred electronically to the third party tester, the software developer electronically maintains control of that software by restricting access to an authorized third party, monitoring testing, and deleting any files related to the prototype software from the third party test workstation.Type: ApplicationFiled: December 21, 2005Publication date: July 20, 2006Applicant: Nintendo Co., Ltd.Inventors: Robert Crombie, Patrick Link, Ben Ong, David McCarten
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Patent number: 6964951Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: August 21, 2002Date of Patent: November 15, 2005Assignee: M.L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Publication number: 20050181428Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present inverition also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: March 22, 2005Publication date: August 18, 2005Inventors: Michael Antoniou, Robert Crombie
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Patent number: 6881556Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: August 21, 2002Date of Patent: April 19, 2005Assignee: M. L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Publication number: 20040161817Abstract: Compositions and methods for the high-level, large-scale production of recombinant proteins are disclosed. Illustrative compositions comprise one or more expression vectors capable of high-level protein and/or polypeptide expression in combination with an immortalized host cell-line capable of growth in serum-free, suspension culture. Bi-directional UCOE vectors that permit the simultaneous, high-level expression of two or more recombinant proteins and/or polypeptides from a single UCOE based plasmid vector.Type: ApplicationFiled: June 4, 2002Publication date: August 19, 2004Applicant: Corixa CorporationInventors: Trish Benton, Christopher Robert Bebbington, Karla Ann Henning, David J. King, Robert Crombie, Xiang Shao
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Patent number: 6689606Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: July 21, 1999Date of Patent: February 10, 2004Assignee: M.L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Publication number: 20030082599Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: May 1, 2003Applicant: WOODCOCK WASHBURN LLPInventors: Michael Antoniou, Robert Crombie
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Publication number: 20030061628Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: March 27, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20030061627Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: March 27, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20030018986Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: January 23, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20020106789Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from13.The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of Figure 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: July 21, 1999Publication date: August 8, 2002Applicant: Cobra therapeutics LimitedInventors: Michael Antoniou , Robert Crombie
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Patent number: 4380166Abstract: The testing apparatus comprises two pressure regulators, two pressure gauges or an optional dual pressure gauge, and valve mechanism. In one embodiment the valve mechanism comprises two valves, namely a power actuated three-way air valve and a power actuated four-way air valve controlled by a mode selector. In an alternative embodiment, the valve mechanism comprises a single three-way air valve controlled by a mode selector. The valves are illustrated in the drawings as solenoid operated valves controlled by electrical selector switches. The testing apparatus has an input line or conduit connectable to two pressure ports of a dual pressure indicator and control unit for pasteurizing equipment. In either embodiment illustrated, actuation of the mode selector places the testing apparatus selectively in tracking or differential test modes.Type: GrantFiled: March 5, 1982Date of Patent: April 19, 1983Inventor: Robert A. Crombie