Abstract: The invention provides a topical cream to treat the pain and inflammation found in a variety of medical disorders. These disorders include, but are not limited to, medical conditions such as arthritis, bursitis and tendonitis. The invention provides two medications, DMSO and PLO gel, to bring pain and inflammation reducing drugs through intact skin. The pain and inflammation reducing drugs are diphenhydramine and ketoprofen (or other non-specific cox inhibitor). It is further anticipated that this compounded formula could be sold O.T.C. (over the counter, without a prescription needed).