Patents by Inventor Robert D. Arbeit

Robert D. Arbeit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20240131037
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: August 27, 2023
    Publication date: April 25, 2024
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20220257586
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2021
    Publication date: August 18, 2022
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • Methods for treating cancer
    Patent number: 11357742
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 14, 2022
    Assignees: X4 Pharmaceuticals, Inc., Georgetown University, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Robert D. Arbeit, Paula Marie Ragan, Michael B. Atkins, James W. Mier, David McDermott
  • Methods for treating cancer
    Patent number: 11337969
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as unresectable or metastatic renal cell carcinoma or kidney cancer, in which X4P-001 or a pharmaceutically acceptable salt thereof is administered as monotherapy or in combination with an immune checkpoint inhibitor, such as nivolumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: May 24, 2022
    Assignee: X4 Pharmaceuticals, Inc.
    Inventor: Robert D. Arbeit
  • Methods for treating immunodeficiency disease
    Patent number: 11219621
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: January 11, 2022
    Assignee: X4 Pharmaceuticals, Inc.
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20210121483
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: January 5, 2021
    Publication date: April 29, 2021
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • Methods for treating cancer
    Patent number: 10953003
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: March 23, 2021
    Assignees: X4 PHARMACEUTICALS, INC., GENZYME CORP.
    Inventors: Paula Marie Ragan, Robert D. Arbeit, Kieran James Crowley
  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20200289532
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: January 17, 2020
    Publication date: September 17, 2020
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20200268739
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: February 28, 2020
    Publication date: August 27, 2020
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • Methods for treating immunodeficiency disease
    Patent number: 10610527
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 7, 2020
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING CANCER
    Publication number: 20190160051
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as unresectable or metastatic renal cell carcinoma or kidney cancer, in which X4P-001 or a pharmaceutically acceptable salt thereof is administered as monotherapy or in combination with an immune checkpoint inhibitor, such as nivolumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.
    Type: Application
    Filed: April 10, 2017
    Publication date: May 30, 2019
    Applicant: X4 Pharmaceuticals, Inc.
    Inventor: Robert D. Arbeit
  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20190142850
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: October 11, 2018
    Publication date: May 16, 2019
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20190083485
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: December 22, 2016
    Publication date: March 21, 2019
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING CANCER
    Publication number: 20190030023
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING CANCER
    Publication number: 20180369229
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Applicants: X4 Pharmaceuticals, Inc., Genzyme Corp.
    Inventors: Paula Marie Ragan, Robert D. Arbeit, Kieran James Crowley
  • METHODS FOR TREATING CANCER
    Publication number: 20180369167
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Inventors: Robert D. Arbeit, Paula Marie Ragan, Michael B. Atkins, James W. Mier, David McDermott
  • Minocycline compounds and methods of use thereof
    Patent number: 10124014
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 13, 2018
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20180015108
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: June 29, 2017
    Publication date: January 18, 2018
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • Minocycline compounds and methods of use thereof
    Patent number: 9724358
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: August 8, 2017
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
  • MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20160228459
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 11, 2016
    Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka