Patents by Inventor Robert D. Barrows

Robert D. Barrows has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC INHIBITORS OF NICOTINAMIDE NMETHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF
    Publication number: 20250368638
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors nicotinamide N-methyltransferase (NNMT). Also disclosed are pharmaceutical compositions comprising a compound disclosed herein. Related methods of treating cancer in a subject and methods of inhibiting tumor growth in subject are also disclosed.
    Type: Application
    Filed: December 23, 2022
    Publication date: December 4, 2025
    Inventors: Matthew D. Shair, Robert D. Barrows, Daniel Edward Jeffries, Mahesh D. Vishe
  • BICYCLIC HETEROAROMATIC INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20250340549
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors nicotinamide N-methyltransferase (NNMT). Also disclosed are pharmaceutical compositions comprising a compound disclosed herein. Related methods of treating cancer in a subject and methods of inhibiting tumor growth in subject are also disclosed.
    Type: Application
    Filed: December 23, 2022
    Publication date: November 6, 2025
    Inventors: Matthew D. Shair, Robert D. Barrows, Daniel Edward Jeffries, Haobin Song, Zhenjie Ma, Ruonan Zhang
  • Compositions and methods for treating malaria
    Patent number: 12370183
    Abstract: Disclosed are methods of treating malaria with tetrahydrobenzonaphtyridine carboxanilide (TBN) derivatives and related pyrrolinones and hydrolysis products thereof. These compounds are active against Plasmodium falciparum strains that are resistant to multiple drugs currently on the market. The present invention further relates to novel compounds and pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: July 29, 2025
    Assignees: Rutgers, The State University of New Jersey, UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Spencer Knapp, Robert D. Barrows, R. Kiplin Guy, Jared Hammill, Christopher Davis
  • COMPOSITIONS AND METHODS FOR TREATING MALARIA
    Publication number: 20230139910
    Abstract: Disclosed are methods of treating malaria with tetrahydrobenzonaphtyridine carboxanilide (TBN) derivatives and related pyrrolinones and hydrolysis products thereof. These compounds are active against Plasmodium falciparum strains that are resistant to multiple drugs currently on the market. The present invention further relates to novel compounds and pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: February 16, 2021
    Publication date: May 4, 2023
    Inventors: Spencer Knapp, Robert D. Barrows, R. Kiplin Guy, Jared Hammill, Christopher Davis