Patents by Inventor Robert D. Collins
Robert D. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190309997Abstract: A combined refrigeration and power plant. The power plant comprises an internal combustion engine an air cycle machine refrigerator driven by the internal combustion engine and configured to refrigerate atmospheric air to provide working fluid to combined refrigeration and power generation cycle, a refrigerated air storage unit configured to store working fluid produced by the air cycle machine refrigerator; and first and second heat exchangers. The first heat exchanger arrangement is configured to exchange heat between a device to be cooled and the working fluid, and the second heat exchanger arrangement is configured to exchange heat between the working fluid downstream of the first heat exchanger in the combined refrigeration and power generation cycle and waste heat from the internal combustion engine; and a generator turbine configured to receive heated working fluid from the second heat exchanger arrangement, and configured to power an electrical generator.Type: ApplicationFiled: July 10, 2017Publication date: October 10, 2019Applicant: ROLLS-ROYCE PLCInventors: Paul FLETCHER, Parag VYAS, Robert D COLLINS, Chloe J PALMER, Stephen G BROWN
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Patent number: 10272133Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: GrantFiled: November 6, 2017Date of Patent: April 30, 2019Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Publication number: 20180050083Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: ApplicationFiled: November 6, 2017Publication date: February 22, 2018Inventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Patent number: 9808501Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: GrantFiled: June 20, 2016Date of Patent: November 7, 2017Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Publication number: 20170042964Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: ApplicationFiled: June 20, 2016Publication date: February 16, 2017Inventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Patent number: 9370549Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: GrantFiled: May 6, 2015Date of Patent: June 21, 2016Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Publication number: 20150250850Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: ApplicationFiled: May 6, 2015Publication date: September 10, 2015Inventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
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Patent number: 9044433Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: GrantFiled: October 5, 2012Date of Patent: June 2, 2015Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy Major
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Patent number: 8932559Abstract: Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.Type: GrantFiled: October 5, 2012Date of Patent: January 13, 2015Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Robert D. Collins, Daniel J. Moore, Jozef Zienkiewicz, Ruth Ann Veach
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Publication number: 20140336113Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.Type: ApplicationFiled: October 5, 2012Publication date: November 13, 2014Applicant: Vanderbilt UniversityInventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy Major
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Patent number: 8324148Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.Type: GrantFiled: December 13, 2002Date of Patent: December 4, 2012Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
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Patent number: 8043576Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.Type: GrantFiled: January 19, 2010Date of Patent: October 25, 2011Assignee: Rolls-Royce plcInventors: Gerard D Agnew, Robert H Cunningham, Philip D Butler, Robert D Collins
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Patent number: 7749465Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.Type: GrantFiled: December 21, 2005Date of Patent: July 6, 2010Assignee: Rolls-Royce plcInventors: Gerard D. Agnew, Robert H. Cunningham, Philip D. Butler, Robert D. Collins
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Publication number: 20100135872Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.Type: ApplicationFiled: January 19, 2010Publication date: June 3, 2010Inventors: Gerard D Agnew, Robert H Cunningham, Philip D Butler, Robert D Collins
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Patent number: 7553929Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.Type: GrantFiled: November 29, 2000Date of Patent: June 30, 2009Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
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Publication number: 20040235746Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.Type: ApplicationFiled: February 20, 2003Publication date: November 25, 2004Inventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
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Publication number: 20040147435Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.Type: ApplicationFiled: December 13, 2002Publication date: July 29, 2004Applicant: Vanderbilt UniversityInventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
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Patent number: 6495518Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.Type: GrantFiled: November 29, 1999Date of Patent: December 17, 2002Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Timmons, Robert D. Collins
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Patent number: 5458857Abstract: A combined reformer and shift reactor comprises a cylindrical reforming chamber arranged within and on the axis of a cylindrical vessel. An annular steam generator is arranged within, and coaxially with, the vessel. The steam generator is arranged around the reforming chamber. A plurality of shift reactors extend axially, with respect to the vessel, through the steam generator. Methane and steam are supplied via helically coiled pipe to the reforming chamber and air is supplied via helically coiled pipe. The methane and steam mixture and air flowing through the pipes are preheated by the reforming chamber product gases flowing in annular passage. The shift reactors convert carbon monoxide and water in the product gases to carbon dioxide and hydrogen and the heat produced is transferred to the water in the steam generator to produce steam.Type: GrantFiled: November 22, 1993Date of Patent: October 17, 1995Assignee: Rolls-Royce, plcInventors: Robert D. Collins, Michael J. Oakley