Patents by Inventor Robert D. Gerard

Robert D. Gerard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apolipoprotein A-1 adenovirus vector compositions and methods
    Patent number: 6503498
    Abstract: The present disclosure demonstrates the successful use of adenovirus mediated gene transfer to increase HDLc in mammalian cells and in mice. BALB/c mice were infected with recombinant adenovirus containing a gene encoding human apolipoprotein A-I (AdCMVApo-I). Immunoreactive apoA-I averaged 168 mg/dl 5 days after infection. HDLc was increased by 35% in infected mice. Lipoprotein analysis revealed that human apoA-I is incorporated into murine HDL particles, producing transient elevations of circulating HDLc of a magnitude correlated with important physiologic effects. Also disclosed are pharmacological preparations to be used to increase serum HDLc in a subject.
    Type: Grant
    Filed: April 5, 1994
    Date of Patent: January 7, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert D. Gerard, Robert S. Meidell, John E. Willard
  • Pai-1 mutants
    Patent number: 5866413
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: February 2, 1999
    Assignee: Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • U-PA mutants resistant to inhibition by their cognate inhibitors
    Patent number: 5728564
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: March 17, 1998
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
    Patent number: 5550042
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 27, 1996
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard