Patents by Inventor Robert D. Ladner

Robert D. Ladner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY WITH DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20230263773
    Abstract: Provided herein are deoxyuridine triphosphatase (dUTPase) inhibitors for use in methods of enhancing a therapeutic efficacy of an immunotherapy agent in a subject in need thereof and in methods of treating cancer in a subject in need thereof, the methods comprising administering to the subject an effective amount of a deoxyuridine triphosphatase (dUTPase) inhibitor and the immunotherapy agent, and optionally further comprising administering to the subject one or more selected from an effective amount of an inhibitor of thymidylate biosynthesis, and an effective amount of an anthracycline or other topoisomerase II inhibitor.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 24, 2023
    Inventors: Robert D. Ladner, Karl Andrew Mulligan, Peter Michael Wilson, Melissa J LaBonte Wilson
  • Nitrogen ring linked deoxyuridine triphosphatase inhibitors
    Patent number: 11518746
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: December 6, 2022
    Assignee: CV6 Therapeutics (NI) Limited
    Inventors: Mark Spyvee, Robert D. Ladner
  • Deoxyuridine triphosphatase inhibitors
    Patent number: 11479531
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: October 25, 2022
    Assignees: University of Southern California, CV6 Therapeutics (NI) Limited
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • Uracil containing compounds
    Patent number: 11247984
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: February 15, 2022
    Assignee: CV6 Therapeutics (NI) Limited
    Inventor: Robert D. Ladner
  • Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
    Patent number: 11198677
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 14, 2021
    Assignees: University of Southern California, CV6 Therapeutics (NI) Limited
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • Hydantoin containing deoxyuridine triphosphatase inhibitors
    Patent number: 11014924
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 25, 2021
    Assignee: CV6 Therapeutics (NI) Limited
    Inventors: Mark Spyvee, Robert D. Ladner
  • NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20210061767
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 6, 2020
    Publication date: March 4, 2021
    Inventors: Mark Spyvee, Robert D. Ladner
  • Deoxyuridine triphosphatase inhibitors
    Patent number: 10889563
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Robert D. Ladner, Bruno Giethlen
  • Nitrogen ring linked deoxyuridine triphosphatase inhibitors
    Patent number: 10829457
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: November 10, 2020
    Assignee: CV6 THERAPEUTICS (NI) LIMITED
    Inventors: Mark Spyvee, Robert D. Ladner
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE
    Publication number: 20200325105
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: February 24, 2020
    Publication date: October 15, 2020
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20200270207
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: March 2, 2020
    Publication date: August 27, 2020
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • Deoxyuridine triphosphatase inhibitors
    Patent number: 10577321
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: March 3, 2020
    Assignees: University of Southern California, CV6 Therapeutics (NI) Limited
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
    Patent number: 10570100
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: February 25, 2020
    Assignees: University of Southern California, CV6 Therapeutics (NI) Limited
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • URACIL CONTAINING COMPOUNDS
    Publication number: 20200039966
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: February 6, 2020
    Inventor: Robert D. Ladner
  • HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20190330210
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: October 31, 2019
    Inventors: Mark Spyvee, Robert D. Ladner
  • Heteroatom containing deoxyuridine triphosphatase inhibitors
    Patent number: 10457673
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 29, 2019
    Assignee: University of Southern California
    Inventors: Robert D. Ladner, Bruno Giethlen
  • NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20190276410
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: September 12, 2019
    Inventors: Mark Spyvee, Robert D. Ladner
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20190270719
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: March 8, 2019
    Publication date: September 5, 2019
    Inventors: Robert D. Ladner, Bruno Giethlen
  • Deoxyuridine triphosphatase inhibitors
    Patent number: 10227326
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 12, 2019
    Assignee: University of Southern California
    Inventors: Robert D. Ladner, Bruno Giethlen
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20180334431
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: July 7, 2016
    Publication date: November 22, 2018
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude