Patents by Inventor Robert D. Leone

Robert D. Leone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal organothiol particles
    Patent number: 6369206
    Abstract: Novel metal-lipid molecules have the formula M—Or—L. M represents a cluster or colloid of atoms of Au, Ag, Pt, Pd, or combinations thereof. Or is an organic group covalently attached to the metal atoms. L represents a lipid moiety. In a preferred embodiment, M represents a cluster of about 50-70 gold atoms having a diameter of about 1.4 nm in diameter and L represents dipalmitoyl phosphatidyl ethanolamine.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: April 9, 2002
    Inventors: Robert D. Leone, James F. Hainfeld
  • Small organometallic probes
    Patent number: 5521289
    Abstract: Small organometallic probes comprise a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe comprises a core of metal atoms surrounded by a shell of organic moieties covalently attached to the metal atoms, a fluorescent molecule, e.g., fluorescein, covalently attached to one of the organic moieties, and a targeting molecule, e.g., an antibody, covalently attached to another of the organic moieties.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: May 28, 1996
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Robert D. Leone, Frederic R. Furuya, Richard D. Powell