Abstract: In general, the present invention relates to uses of voltage-gated sodium channel blocker compounds, which include corresponding precursors, intermediates, monomers and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory and respiratory tract diseases. In particular, the present invention also relates to methods and uses for treatment of respiratory or respiratory tract diseases, which comprises administering to a subject in need thereof an effective amount of a compound of the present invention.

Abstract: On an “upright” vacuum cleaner, instead of a single handle, two handles. When in use, the handles are positioned horizontally level with one another, either side of a line running from front to rear of the vacuum cleaner.

Abstract: This invention relates to a method for increasing the dose of a PDE4 inhibitor that can be administered at one time and be tolerated by the patient by reducing the absorption rate or the rate of rise in plasma concentration of the inhibitor.