Abstract: This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a monoester of probucol, particularly the monosuccinic acid ester, or a pharmaceutically acceptable salt or derivative thereof.

Abstract: This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a monoester of probucol, particularly the monosuccinic acid ester, or a pharmaceutically acceptable salt or derivative thereof.

Abstract: Methods and compositions for the treatment or prophylaxis of a disorder associated with platelet activation or enhanced thrombin activity are provided, that include the administration of an effective amount of a compound of the formula: or its pharmaceutically acceptable salt, ester or prodrug, wherein the substituents are defined herein, optionally in the appropriate pharmaceutically acceptable carrier for the route of administration selected.

Abstract: This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a compound including an optionally substituted phenyl ring linked to an aromatic or alkyl group by a spacer, wherein the spacer includes two groups selected from selenium, sulfur, S(O) and S(O)2 and may include an alkylene, alkenylene, cycloalkylene or arylene moiety between the selenium, sulfur, S(O) or S(O)2 groups, or a pharmaceutically acceptable salt or derivative thereof.

Abstract: This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a monoester of probucol, particularly the monosuccinic acid ester, or a pharmaceutically acceptable salt or derivative thereof.

Abstract: A clean room ceiling having an air impervious filter support and air flow path-defining filters supported by the support, and a permanently fluid, nonevaporative non-air-flow-displaceable gel blocking air flow past the support except along the filter defined air path.

Abstract: Method and system are provided for the automated assembly of parts such as plastic parts into assemblies wherein assembly pallets loaded with their corresponding assemblies are stored and vertically indexed in an accumulator station to allow a previously applied material such as an adhesive to cure. Consequently, the system takes up little floor space. Entrance, dispensing and assembly stations, together with the accumulator station each has an enclosed chamber which is pressurized with an ambient at subatmospheric pressure in order to evacuate the enclosed chambers so that fumes from the adhesive utilized in securing the parts together are not allowed to escape at the stations during assembly of the parts.

Abstract: A valve construction which may be used to control the flow of any desired fluid in any desired valving action and which provides an interchangeable and removable activating means and an interchangeable and removable valve cartridge assembly of the lap spool, packed spool, proportional flow or any other version. The valve comprises a removable and interchangeable activating means, a removable and interchangeable cap assembly, a novel housing adapted to accept a removable and interchangeable valve cartridge assembly of the lap spool, packed spool, proportional flow, or any other version, and a removable and interchangeable valve cartridge assembly of the lap spool, packed spool, proportional flow, or any other version comprised of a plunger and separator means.

Abstract: Wearable, continuously internally operable, externally regenerable dialysis system in which body fluids are dialyzed against a first dialysis fluid within a chamber in the body without invasion of veins or arteries, the chamber being a body cavity or a semi-permeable wall within the body, the dialysis fluid being regenerated in a chamber outside the body against a second dialysis fluid which is continuously regenerated in a belt supported apparatus, the internal and external chambers being in fluid communication.

Abstract: Faithful replication of a drummer's hits on an electric drum, free of cogeneration of spurious signals by acoustic coupling of the drum pick-up with extraneous energy sources such as nearby musical instruments is achieved by employing as the drum hit pick-up a variable resistance transducer comprising a foamed dielectric matrix, e.g. polymer, having electroconductive particles therein, sandwiched between conductive members one of which is contiguous with the drum head.

Abstract: A battery charging circuit employing three operational amplifiers, one to sense charging current and two to regulate constant voltage charging, one for low rate or float level and one for high rate charging. A resistance element acts as part of the current sensing circuit and also limits charge current. A Zener diode provides a voltage reference and aids in sensing deviations of actual terminal voltage from desired terminal voltage to provide feedback control to the voltage regulating operational amplifiers.

Abstract: A dynamic loudspeaker is driven by chopped d.c. from the collector of a transistor. A free wheeling diode is connected in parallel with the speaker circuit to dissipate the inductive energy in the speaker voice coil when the transistor is turned off. The transistor is controlled by a voltage controlled oscillator which, under control of other elements, can be made to produce a wide variety of cyclically varying output signals for producing a wide range of sounds, tones and signals from the loudspeaker. This permits selection of a tone which differs sufficiently from the ambient noise to assure attracting attention. By the use of chopped d.c. to drive the speaker, the expense, weight and bulk of an impedance matching transformer is eliminated. A plurality of individually operable switches are provided for switching circuit elements in and out of circuit to modify wave shapes and alter sound output.

Abstract: Wearable, self-contained and fully mobile personal breathing apparatus adapted to be worn by a surgeon or other operating room personnel is provided. The apparatus controls contamination of operating room spaces generated by the air normally expired by the wearer during surgery. The apparatus comprises a vest, a high efficiency particulate air filter secured to said vest, and conduit means for capturing and directing contaminated exhaled air from the wearer through the upstream side of said filter and a blower connected to the downstream side of said filter for inducing air flow in the conduit means and through the filter for decontamination and return to the operating room space.