Patents by Inventor Robert D. Simoni

Robert D. Simoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesyl compounds as farnesyl protein transferase inhibitors to treat ras induced tumor growth
    Patent number: 5567729
    Abstract: Farnesyl derivatives, particularly farnesyl acetate, are used to reduce the level of protein farnesylation in a mammalian host. The activity of proteins which require farnesylation for function is thereby reduced. The compounds may be administered to patients to reduce the overall level of ras protein activity, either alone or in conjunction with other drugs which act as competitive inhibitors of farnesyl protein transferase.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: October 22, 1996
    Assignees: David L. Bradfute, Thomas E. Meigs, Robert D. Simoni
    Inventors: David L. Bradfute, Robert D. Simoni, Thomas E. Meigs
  • Farnesyl compounds as cholesterol lowering agents
    Patent number: 5475029
    Abstract: Farnesyl derivatives, particularly farnesyl acetate, are used to lower the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in cells, thereby reducing cholesterol biosynthesis. The compounds may be administered to hypercholesterolemia patients to reduce the overall level of serum cholesterol, either alone or in conjunction with other drugs conventionally used for the treatment of hypercholesterolemia.
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: December 12, 1995
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David L. Bradfute, Robert D. Simoni