Patents by Inventor Robert D. Titus

Robert D. Titus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
    Patent number: 5637767
    Abstract: A method of making (.+-.)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating the ##STR5## to form ##STR6## hydrolyzing the ##STR7## with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (.+-.)-3-(aminomethyl)-5-methylhexanoic acid, wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, benzyl, or C.sub.3 -C.sub.6 cycloalkyl. The present invention also provides a method of making (.+-.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Warner-Lambert Company
    Inventors: Todd M. Grote, Brian K. Huckabee, Thomas Mulhern, Denis M. Sobieray, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
    Patent number: 5637624
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 9, 1993
    Date of Patent: June 10, 1997
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
    Patent number: 5571942
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: November 5, 1996
    Assignee: Eli Lilly and Company
    Inventors: Craig S. Hoechstetter, Diane L. Huser, John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5552444
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: September 3, 1996
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes
    Patent number: 5470977
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: November 28, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5466709
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: November 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c> pyrroles as inhibitors of serotonin reuptake
    Patent number: 5457121
    Abstract: This invention provides ring-substituted cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles which are selective inhibitors of serotonin reuptake.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5426229
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: June 20, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
    Patent number: 5426226
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor. An intermediate for preparing the novel compounds have the following formula: ##STR1## wherein R, R.sub.1 and R.sub.9, are as defined in the specification.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: June 20, 1995
    Inventors: Craig S. Hoechstetter, Diane L. Huser, John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
    Patent number: 5389687
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which exhibit binding activity at the serotonin 1A receptor.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: February 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pharmaceutical compositions thereof
    Patent number: 5286753
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: February 15, 1994
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
    Patent number: 5026707
    Abstract: This invention provides ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which are selective inhibitors of serotonin reuptake.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: June 25, 1991
    Assignee: Eli Lilly and Company
    Inventors: James A. Nixon, Richard P. Pioch, John M. Schaus, Robert D. Titus
  • Octahydro-oxazolo[4,5-g]quinolines derivatives and decahydro quinoline intermediates and their use as dopamine D-2 agonists
    Patent number: 4698347
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: December 11, 1986
    Date of Patent: October 6, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Process for the preparation of octahydro-oxazolo [4,5-G]quinolines
    Patent number: 4659832
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: April 21, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(.+-.) and tran(.+-.)isomers so prepared
    Patent number: 4600777
    Abstract: 1-C.sub.1-3 straight chain alkyl 7-oxodecahydroquinoline, chemical intermediates.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus, Robert D. Titus, Leland O. Weigel
  • Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
    Patent number: 4537893
    Abstract: Trans-(.+-.) 2 and/or 5-permissibly substituted octahydrothiazolo[4,5-g]quinolines and acid addition or quaternary salts thereof and, individual enantiomers thereof, useful as dopamine agonists.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: Robert D. Titus, Edmund C. Kornfeld
  • Hydroxyaminotetralincarboxamides
    Patent number: 4500545
    Abstract: o-Hydroxy tetralin carboxamides, substituted with an amino group in the aliphatic ring, are dopamine agonists.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 19, 1985
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld, Robert D. Titus
  • Hydroxyaminotetralincarboxamides
    Patent number: 4448990
    Abstract: o-Hydroxy tetralin carboxamides, substituted with an amino group in the aliphatic ring, are dopamine agonists.
    Type: Grant
    Filed: November 16, 1982
    Date of Patent: May 15, 1984
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld, Robert D. Titus