Patents by Inventor Robert D. van Reis
Robert D. van Reis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7153426Abstract: The invention relates to charged filtration membranes and their use for separation of a protein from solvent, low molecular weight solutes or a mixture of proteins. Modification of the membranes to generate charge includes modification of membrane pores to alter charge within a pore and alter the size of a pore. Consequently, the protein is separated from other solutes in a mixture based on size as well as net protein charge and membrane charge.Type: GrantFiled: September 29, 2005Date of Patent: December 26, 2006Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 7001550Abstract: The invention relates to charged filtration membranes and their use for separation of a protein from solvent, low molecular weight solutes or a mixture of proteins. Modification of the membranes to generate charge includes modification of membrane pores to alter charge within a pore and alter the size of a pore. Consequently, the protein is separated from other solutes in a mixture based on size as well as net protein charge and membrane charge.Type: GrantFiled: April 16, 2003Date of Patent: February 21, 2006Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 6926833Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: GrantFiled: April 22, 2003Date of Patent: August 9, 2005Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Publication number: 20030178368Abstract: The invention relates to charged filtration membranes and their use for separation of a protein from solvent, low molecular weight solutes or a mixture of proteins. Modification of the membranes to generate charge includes modification of membrane pores to alter charge within a pore and alter the size of a pore. Consequently, the protein is separated from other solutes in a mixture based on size as well as net protein charge and membrane charge.Type: ApplicationFiled: April 16, 2003Publication date: September 25, 2003Inventor: Robert D. van Reis
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Publication number: 20030178367Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: ApplicationFiled: April 22, 2003Publication date: September 25, 2003Inventor: Robert D. van Reis
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Patent number: 6555006Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: GrantFiled: April 12, 2002Date of Patent: April 29, 2003Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Publication number: 20020108907Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: ApplicationFiled: April 12, 2002Publication date: August 15, 2002Inventor: Robert D. Van Reis
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Patent number: 6387270Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: GrantFiled: October 19, 2000Date of Patent: May 14, 2002Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 6221249Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture of a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: GrantFiled: February 10, 2000Date of Patent: April 24, 2001Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 6054051Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.Type: GrantFiled: December 17, 1996Date of Patent: April 25, 2000Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 6027650Abstract: The present invention relates to methods useful for purifying materials using adsorbent chromatography, preferably in an expanded bed or packed bed configuration without the need to use a moving packed bed adapter, thereby improving elution characteristics for the sample molecule of interest.Type: GrantFiled: February 16, 1999Date of Patent: February 22, 2000Assignee: Genentech, Inc.Inventors: Robert D. Van Reis, Gerardo A. Zapata
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Patent number: 5490937Abstract: Processes and apparati are provided for separating species of interest from a mixture containing them which comprises subjecting the mixture to tangential-flow filtration, wherein the filtration membrane preferably has a pore size that retains species with a size up to about 10 microns, and the flux is maintained at a level ranging from about 5 % up to 100 % of transition point flux.Type: GrantFiled: July 6, 1994Date of Patent: February 13, 1996Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 5256294Abstract: Processes and apparati are provided for separating species of interest from a mixture containing them which comprises subjecting the mixture to tangential-flow filtration, wherein the filtration membrane preferably has a pore size that retains species with a size up to about 10 microns, and the flux is maintained at a level ranging from about 5% up to 100% of transition point flux.Type: GrantFiled: September 17, 1990Date of Patent: October 26, 1993Assignee: Genentech, Inc.Inventor: Robert D. van Reis
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Patent number: 5053334Abstract: A method of producing biologically active human tissue plasminogen activator in suspension culture is provided wherein recombinant Chinese hamster ovary cells are cultured and certain components detrimental to recovery and biological activity are removed as a cell-free filtrate by cross-flow filtration. The human tissue plasminogen activator is recovered from the culture medium.Type: GrantFiled: May 9, 1990Date of Patent: October 1, 1991Assignee: Genentech, Inc.Inventors: William R. Arathoon, Stuart E. Builder, Anthony S. Lubiniecki, Robert D. van Reis