Abstract: A class of medically-effective formulations comprising cannabinoids, and terpenes, using ?-myrcene to improve effectiveness. B-myrcene decreases resistance across the blood-brain barrier for both itself and a plurality of other medically-active compounds such as other terpenes, cannabinoids, and flavonoids. Further, ?-myrcene has been determined to raise the saturation level of the cannabinoid receptor CB1 for phytocannabinoids such as delta(9)-tetrahydrocannabinol, and to increase cell membrane permeability for itself as well as cannabinoids, terpenes, flavonoids and other naturally occurring cannabis compounds, thereby improving therapeutic benefits of cannbis formulations.