Patents by Inventor Robert Darrin Wilson

Robert Darrin Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutically acceptable salts of 2-{4-[(3)-piperidin-3-yl]phenyl}-2-indazole-7-carboxamide
    Patent number: 8436185
    Abstract: The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: May 7, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jennifer R. Foley, Robert Darrin Wilson
  • Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
    Patent number: 8168799
    Abstract: A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: May 1, 2012
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: Michael Stewart Ashwood, Matthew Bio, Edward Cleator, David Hands, Faye Julia Sheen, Robert Darrin Wilson
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE
    Publication number: 20100286203
    Abstract: The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 11, 2010
    Inventors: Jennifer R. Foley, Robert Darrin Wilson
  • Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
    Publication number: 20100174091
    Abstract: A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.
    Type: Application
    Filed: April 20, 2006
    Publication date: July 8, 2010
    Inventors: Michael Stewart Ashwood, Matthew Bio, Edward Cleator, David Hands, Faye Julia Sheen, Robert Darrin Wilson
  • Process for preparing peptide intermediates
    Patent number: 7262169
    Abstract: The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: August 28, 2007
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Limited
    Inventors: Michael Stewart Ashwood, Brian Christopher Bishop, Ian Frank Cottrell, Khateeta Moneek Emerson, David Hands, Guo Jie Ho, Joseph Edward Lynch, Yao Jun Shi, Robert Darrin Wilson
  • Chemical synthesis of 1,2,4-triazolinone derivative
    Patent number: 6407255
    Abstract: The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: June 18, 2002
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Ian Frank Cottrell, Ulf H Dolling, David Hands, Robert Darrin Wilson
  • Chemical synthesis of morpholine derivatives
    Publication number: 20020019524
    Abstract: 1
    Type: Application
    Filed: September 10, 2001
    Publication date: February 14, 2002
    Applicant: Merck Sharp & Dohme Limited
    Inventors: Ian Frank Cottrell, Ulf H. Dolling, David Hands, Robert Darrin Wilson
  • Chemical synthesis of morpholine derivatives
    Patent number: 6297376
    Abstract: The present invention relates to a process for the preparation of mopholine derivatives of formula (I) which are useful as a therapeutic agents.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: October 2, 2001
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Ian Frank Cottrell, Ulf H Dolling, David Hands, Robert Darrin Wilson