Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: Provided herein is a method of obtaining an extract from a plant biomass as well as an extract obtained from the method. Also provided is a pharmaceutical product, ODF, nutraceutical product, and/or edible product, that includes the extract and one or more excipients. Also provided is a method that includes orally administering the extract (or pharmaceutical product, ODF, nutraceutical product, and/or edible product, that includes the extract).

Abstract: Provided is an oral soft gel capsule that includes a psychedelic compound. Also provided is a method of treating in a subject a disease or disorder ameliorated by a psychedelic compound, that includes orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a low dose (e.g., microdose or sub-therapeutic dose) of the psychedelic compound.

Abstract: Provided herein is a method of obtaining an extract from a plant biomass as well as an extract obtained from the method. Also provided is a pharmaceutical product, ODF, nutraceutical product, and/or edible product, that includes the extract and one or more excipients. Also provided is a method that includes orally administering the extract (or pharmaceutical product, ODF, nutraceutical product, and/or edible product, that includes the extract).

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: Provided is an oral soft gel capsule that includes a psychedelic compound. Also provided is a method of treating in a subject a disease or disorder ameliorated by a psychedelic compound, that includes orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a low dose (e.g., microdose or sub-therapeutic dose) of the psychedelic compound.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: A faucet including a spring spout supporting a spout nest, and a sprayhead releasably coupled to the spout nest. A docking cradle is supported by the spout base and is configured to releasably couple to the spout nest. The faucet may include a capacitive sensor operably coupled to the spring spout by at least one capacitive coupling.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

Abstract: Methods and an apparatus for creation of physical articles of merchandise and associated virtual articles of merchandise based on a user selection of an image, such as a photo. A non-fungible token (NFT) may be associated with one or both of a physical article of merchandise and virtual article of merchandise, or associated with the image selected by the user. The NFT may be transferred with one or both of physical article of merchandise and virtual article of merchandise.

Abstract: Genetically engineered antibodies containing non-native N-glycosylated sites, preparation of the antibodies in yeast and fungi, site-specific conjugation of drugs to these antibodies, and methods of treatment utilizing these antibodies are described herein.

Abstract: The present invention provides a method for producing a magnetic nanoparticle-coated laminate material. The method comprises coating a pair of opposed surfaces of a plurality of steel or iron/cobalt (Fe/Co) alloy film portions with a magnetic nanoparticle-containing coating. Each magnetic nanoparticle comprises a core and a shell covering at least a portion of the core. The shell and core are made of different materials selected from one or more of: iron, cobalt, nickel; and/or alloys comprising two or more of: iron, cobalt and/or nickel; and/or magnetic rare earth metals; and/or diamagnetic transition metals. The method further comprises stacking the coated film portions on top of each other such that a or each coated surface of each film portion is located adjacent a further coated surface of an adjacent film portion; and compressing the stacked coated film portions together to form a nanoparticle-coated laminate material.

Abstract: Genetically engineered antibodies containing non-native N-glycosylated sites, preparation of the antibodies in yeast and fungi, site-specific conjugation of drugs to these antibodies, and methods of treatment utilizing these antibodies are described herein.

Abstract: A smart shower sensor configured to be fluidly coupled to a showerhead. The smart shower sensor is configured to provide notifications and/or transmit notifications to other smart devices based on, for example, water temperature and/or water usage.

Abstract: The invention provides a liquid-dispersible powder comprising nanoscale grains of matrix embedded with one or more isolated nanoparticles and a composition for the magnetic nanoparticle hyperthermia (MNH) treatment of tumours comprising nanoscale grains of matrix material containing one or more isolated nanoparticles. The invention also provides a method of production of a liquid-dispersible powder described herein, the method comprising the steps of providing nanoparticles prepared under ultra-high vacuum (UHV) gas phase conditions; co-depositing the nanoparticles within a matrix material under UHV gas phase conditions; and grinding the film to a fine powder comprising grains of groups of matrix material isolated nanoparticles.

Abstract: A method of making a waveguiding optical component includes processing a polymer optical material to form a billet having an axis of light transmission and having residual stress maintaining a transverse extent of the billet; placing the billet into a mold, the mold being configured to constrain transverse expansion of the billet according to a desired shape of the waveguiding optical component; and heating the billet in the mold to induce relaxation of the residual stress and corresponding transverse expansion of the billet, thereby forming the billet into the waveguiding optical component with the desired shape. An alternative method begins with a collection of individual canes or fiber segments which are fused during the heating process, bypassing a separate process of forming a billet.