Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.

Abstract: A refuse vehicle includes a chassis, a body, a lock, a tailgate, an ejector, an actuator, a second actuator, and a processor. The body defines a receptacle for storing refuse. The lock is coupled to the body and is configured to releasably secure a movable tailgate. The receptacle contains the ejector. The ejector can transition from a first position that is spaced from the tailgate to a second position proximate the tailgate. The actuator is configured to transition the ejector from the first position to the second position. The second actuator is configured to move the tailgate. The processor is configured to selectively unlock the tailgate and transition the ejector from the first position to the second position in response to receiving a single input to thereby eject refuse from the receptacle without receiving multiple inputs.

Abstract: A range extension system for a refuse vehicle includes a battery, and a controller. The battery is configured to provide electrical energy for accessories of the refuse vehicle. The controller is configured to obtain a state of charge of the battery and limit operation of at least one of the accessories in response to the state of charge of the battery to extend a transportation range of the refuse vehicle.

Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: A refuse vehicle includes multiple tractive elements, a prime mover, and an independent accessory system. The prime mover is configured to generate mechanical energy to drive one or more of the tractive elements. The independent accessory system includes one or more storage tanks configured to store a fuel, and an accessory primary mover. The accessory primary mover is configured to fluidly couple with the one or more storage tanks to receive the fuel from the one or more storage tanks and operate to pressurize a hydraulic fluid to drive an accessory of the refuse vehicle. The accessory primary mover is configured to pressurize the hydraulic fluid to drive the accessory of the refuse vehicle independently of operation of the prime mover.

Abstract: The disclosure provides methods for the acute treatment of depression and/or anxiety, for the enhancement of mTOR (e.g., mTORC1) signaling, and for the reduction of neuroinflammation, comprising administering to a patient in need thereof, a therapeutically effective amount of a 5-HT2A/mu-opioid receptor or 5-HT2A/D1 and/or D2/mu-opioid receptor ligand.

Abstract: An apparatus, system and related methods for controlling a pressurized flow from a high or low pressure system. An actuated sand dump system and related methods include a first valve positioned downstream of a high or low pressure system, a second valve positioned downstream of the first valve, a choke positioned between in the first and second valves, a plurality of pressure gauges, and a control unit operable to automatically open and close the first and second valves and the choke in a predetermined sequence, upon initiating the predetermined sequence, and in response to pressure measurements from the plurality of pressure gauges.

Abstract: The disclosure provides methods for the treatment of Bipolar II Disorder, comprising administering to a patient in need thereof, a therapeutically effective amount of lumateperone, in free or pharmaceutically acceptable salt form, optionally in deuterated form.

Abstract: According to an aspect of the present invention disclosed herein, there is provided buckle, comprising: a male component and a female component, wherein: the male component comprises: a slot for a strap at an end of the male component opposite the side where the male component is configured to insert into the female component; an inclined insert; and one or more mating slots in the inclined insert; and the female component comprises: a top wall, a bottom wall, and sidewalls forming a receiving portion; a plurality of teeth; a slot for a strap; and a chord, wherein the chord is configured that when pulled the teeth disengage just enough for the male component to be released.

Abstract: One embodiment of a method for reducing network congestion cause by multicast communications includes receiving, via a network, first data associated with one or more multicast operations, determining a congestion state of the network based on the first data, and performing one or more operations to reduce an amount of second data that is transmitted via the network based on the congestion state of the network.

Abstract: A refuse vehicle includes a chassis, a vehicle body supported by the chassis, a lift assembly, and a projector. The vehicle body defines a receptacle for storing refuse. The lift assembly is configured to selectively engage a waste container. The lift assembly is movable between a first position and a second position. The projector is positioned to emit light outwardly away from the refuse vehicle and proximate the lift assembly to define a target area.

Abstract: The present disclosure relates to a composition that includes a poly(hydroxy)urethane (PHU) foam, a phase change material (PCM), and a solid additive, where the PHU foam includes a plurality of voids, at least a portion of the voids contain the PCM and the solid additive, and the composition is capable of being repeatedly cycled through a temperature range, resulting in the PCM cycling between a solid phase and a liquid phase. In some embodiments of the present disclosure, the PCM may include at least one of a hydrated salt, a paraffin wax, a sugar alcohol, a fatty acid, and/or a eutectic mixture.

Abstract: A refuse vehicle includes a chassis, an energy storage device, a body, an electric power take-off system, and a disconnect. The energy storage device is supported by the chassis and is configured to provide electrical power to a prime mover. Activation of the prime mover selectively drives the refuse vehicle. The body is supported by the chassis and defines a receptacle for storing refuse. The electric power take-off system is positioned on the refuse vehicle, and includes a motor that is configured to drive a hydraulic pump to convert electrical power received from the energy storage device into hydraulic power. The disconnect is positioned between the energy storage device and the electric power take-off system and is configured to selectively decouple the electric power take-off system from the energy storage device.

Abstract: A fiber catching device includes a base having an inboard portion and an outboard portion, an external wall extending upwardly from the inboard portion of the base, an outboard hook extending upwardly from the outboard portion of the base and extending to a height above the external wall, and at least one receiver disposed between the external wall and the outboard hook. In one variation, a plurality of protrusions are disposed on the external wall and define a plurality of gaps there between.

Abstract: A refuse vehicle includes a chassis, a first energy storage device, a body, an electric power take-off system, and a subsystem coupled to the body and moveable using hydraulic power from the electric power take-off system. The first energy storage device (e.g., a battery) is supported by the chassis and is configured to provide electrical power to a prime mover. Activation of the prime mover selectively drives the refuse vehicle. The body is configured for storing refuse, and is supported by the chassis. The electric power take-off system is positioned on the body and includes an electric motor, a second energy storage device configured to provide electric power to the electric motor, and a hydraulic pump that is drive by the electric motor. The electric motor drives the hydraulic pump to convert the electrical power into hydraulic power.

Abstract: Systems, methods, and computer-readable media are described for combining digital and analog beamsteering in a channelized antenna array. In some examples, a method can include receiving one or more signals at each of a plurality of groups of antenna elements, each group of antenna elements defining a respective channel from a plurality of channels, and steering, by each respective channel and using analog steering, the one or more signals in a respective direction to yield a steered analog signal pattern. The method can further include converting the steered analog signal pattern associated with each respective channel into a respective digital signal and, based on the respective digital signal, generating, using digital steering, digital signal patterns steered within the steered analog signal pattern associated with the respective digital signal.

Abstract: A refuse vehicle includes a chassis, an energy storage device, a vehicle body, an electric power take-off system, and a hydraulic component. The energy storage device is supported by the chassis and is configured to provide electrical power to a prime mover. Activation of the prime mover selectively drives the refuse vehicle. The vehicle body is supported by the chassis, and includes an on-board receptacle for storing refuse therein. The electric power take-off system is positioned on the vehicle body, and includes an electric motor configured to drive a hydraulic pump to convert electrical power received from the energy storage device into hydraulic power. An amount of electrical power at least one of received by and provided to the electric motor is limited by a controller to control an output characteristic of the hydraulic pump. The hydraulic component is in fluid communication with the hydraulic pump and configured to operate using hydraulic power from the electric power take-off system.

Abstract: The present invention relates to methods for reducing soluble P-selectin and major thrombotic events in cancer patients.

Abstract: A non-transitory computer-readable media comprising computer-readable instructions stored thereon that, when executed by a processor, causes the processor to generate a route, control a drone to surveil an area along the route, generate, from a sensor on the drone, status data for one or more refuse containers, analyze the status data to determine a status of refuse within the area, provide a notification to a customer based on the status of refuse, repeat surveillance to determine if the status of refuse has changed, generate a revised route in response to determining that the status of refuse has changed, and update a customer bill in response to determining that the status of refuse has changed.

Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.