Abstract: The disclosure relates to the combination of inhibitors of phosphodiesterase 1 (PDE1) useful for the treatment of certain cancers or tumors, such as gliomas. In another embodiment, the disclosure relates to the combination of inhibitors of PDE1 and an antitumor agent for the treatment of certain cancers or tumors, such as gliomas.

Abstract: The present invention relates to an adjustable and field-repairable metal buckle system designed for use in high-performance, load-bearing applications such as tactical gear. This buckle system includes a female buckle housing, a male buckle component, and an interchangeable slide bar equipped with a ball-lock and captive screw mechanism, which enables secure positioning and easy release. The female housing contains a locking mechanism with spring-biased arms that interlock with the male component, ensuring a load-bearing connection. The slide bar features a slit for easy insertion and removal of webbing loops, facilitating field repairability. Configurations include a 5.5-inch slide for side release and smaller 1.5-inch and 1-inch slides for shoulder release applications, allowing customizable functionality.

Abstract: Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of agitation, aggressive behaviors, posttraumatic stress disorder or impulse control disorders.

Abstract: Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of agitation, aggressive behaviors, posttraumatic stress disorder or impulse control disorders.

Abstract: The present invention relates to an adjustable and field-repairable metal buckle system designed for use in high-performance, load-bearing applications such as tactical gear. This buckle system includes a female buckle housing, a male buckle component, and an interchangeable slide bar equipped with a ball-lock and captive screw mechanism, which enables secure positioning and easy release. The female housing contains a locking mechanism with spring-biased arms that interlock with the male component, ensuring a load-bearing connection. The slide bar features a slit for easy insertion and removal of webbing loops, facilitating field repairability. Configurations include a 5.5-inch slide for side release and smaller 1.5-inch and 1-inch slides for shoulder release applications, allowing customizable functionality.

Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: According to an aspect of the present invention disclosed herein, there is provided buckle, comprising: a male component and a female component, wherein: the male component comprises: a slot for a strap at an end of the male component opposite the side where the male component is configured to insert into the female component; an inclined insert; and one or more mating slots in the inclined insert; and the female component comprises: a top wall, a bottom wall, and sidewalls forming a receiving portion; a plurality of teeth; a slot for a strap; and a chord, wherein the chord is configured that when pulled the teeth disengage just enough for the male component to be released.

Abstract: A computer-implemented method includes forecasting an estimated linear reach for a future ad campaign based at least in part on historical linear ad campaign data. The computer-implemented method also includes forecasting an estimated digital reach for the future ad campaign based at least in part on historical digital ad campaign data. The computer-implemented method also includes determining an estimated audience duplication based at least in part on the estimated linear reach and the estimated digital reach. The computer-implemented method also includes determining an estimated cross-platform reach based at least in part on the estimated linear reach, the estimated digital reach, and estimated audience duplication.

Abstract: The disclosure relates to the combination of inhibitors of phosphodiesterase 1 (PDE1) useful for the treatment of certain cancers or tumors, such as colon cancer. In another embodiment, the disclosure relates to the use of inhibitors of PDE1 and an optional antitumor agent for the treatment of certain cancers or tumors.

Abstract: A system includes a memory storing computer-readable instructions, and at least one processor to execute the instructions to receive an alias for a user, the alias representing a particular person, transmit a request to a server computing device, the request comprising a representation of the alias, query at least one database using the representation of the alias to determine a realtime physical address for the particular person, receive a response from the server computing device, the response comprising an encrypted representation of the realtime physical address for the particular person, and decrypt the realtime physical address for the particular person by the server computing device and send at least one object to the realtime physical address for the particular person.

Abstract: The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

Abstract: The invention relates to particular deuterated substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.

Abstract: A system includes a memory storing computer-readable instructions, and at least one processor to execute the instructions to receive an alias for a user, the alias representing a particular person, transmit a request to a server computing device, the request comprising a representation of the alias, query at least one database using the representation of the alias to determine a realtime physical address for the particular person, receive a response from the server computing device, the response comprising an encrypted representation of the realtime physical address for the particular person, and decrypt the realtime physical address for the particular person by the server computing device and send at least one object to the realtime physical address for the particular person.

Abstract: Systems and methods for efficient and reliable supplemental content scheduling within primary content of a linear platform are provided. Specifically, a placement context is used to identify a suitable placement model from a plurality of placement models. The scheduling of future placements of the supplemental content via the linear platform is determined by applying historical linear impressions to the suitable placement model.

Abstract: The disclosure provides methods for the acute treatment of depression and/or anxiety, for the enhancement of mTOR (e.g., mTORC1) signaling, and for the reduction of neuroinflammation, comprising administering to a patient in need thereof, a therapeutically effective amount of a 5-HT2A or 5-HT2A/D2 receptor ligand, e.g. lumateperone.

Abstract: A compact broadband antenna system for a water meter module including a dual-band monopole antenna system having an elongated ground plane, spiral radiating elements that enable operation in a first frequency band, and patch radiating elements that enable operation in a second frequency band, separate from and higher than the first frequency band. The water meter module may include a water-tight enclosure to house the dual-band-monopole antenna system and other components.

Abstract: Described herein are examples of systems, methods, apparatuses, and devices which include a carbon nanotube structure. The carbon nanotube structure may include a first carbon nanotube with a first top surface and a first bottom surface. The carbon nanotube structure may include a second carbon nanotube vertically aligned with the first carbon nanotube. The second carbon nanotube may include a second top surface and a second bottom surface. The first carbon nanotube and the second carbon nanotube may be infiltrated with carbon by a mixture that is flowing. The mixture may include a first amount of ethylene and a second amount of hydrogen. The carbon nanotube structure may include a thin film extending along the first bottom surface and the second bottom surface.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: A global intelligence platform integrating satellite imagery, media analysis, and AI-driven insights. The system comprises a data integration module for processing real-time data streams, an AI analytics engine with machine learning models for each data type, a data fusion module for correlating insights, and a user interface. The AI engine includes models for analyzing satellite imagery, translating, and summarizing news, and processing social media sentiment. The data fusion module spatiotemporally aligns the heterogeneous data to identify relationships and generate a unified knowledge representation. The user interface enables querying, filtering, and customizing intelligence reports. By leveraging advanced AI techniques and diverse data sources, the invention provides comprehensive, real-time intelligence for decision-makers across various sectors, empowering informed responses to global events, trends, and public sentiment.