Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A method and system for optimizing memorization of stored content. One or more discrete units of content selected for memorization are obtained. The units of content as displayed to the user according to a pre-determined order. Feedback is received from the user indicating the level of memorization achieved by the user corresponding to the displayed units of content. The subsequent order to display content is adjusted to achieve an optimized order for memorization based on the feedback received.

Abstract: Preferred embodiments of a combination group couponing and member-only product discounting system and methods.

Abstract: A method and system for optimizing memorization of stored content. One or more discrete units of content selected for memorization are obtained. The units of content as displayed to the user according to a pre-determined order. Feedback is received from the user indicating the level of memorization achieved by the user corresponding to the displayed units of content. The subsequent order to display content is adjusted to achieve an optimized order for memorization based on the feedback received.

Abstract: A method for implementing a course hub can include generating a three dimensional activity grading object. Furthermore, an assessable learner process journal can be generated as part of implementing the course hub. In addition, the implementing of the course hub can include generating a plurality of communication zones. Moreover, a “what if” assignment grade modeling can be generated as part of implementing the course hub.

Abstract: A printer, scanner device and methods for using same are described herein. A printer device may include a dedicated input that, when actuated, generates and sends a request to a computer for known data or a predetermined print job, e.g., schedule information from a personal information management (PIM) application. A scanner device may include another dedicated input that, when actuated, automatically scans a document fed to the device by the user and sends the scanned image to IM (or other) software on a computer, bypassing the need to manipulate the scanned image using scanner software. The device may be used with printed metapaper, which includes a barcode or other indicia identifying the metapaper and corresponds to a stored template image of the metapaper. When the metapaper is rescanned, the scan can be compared to the stored template information to identify changes and synchronize the changes with the IM software.

Abstract: A printer, scanner device and methods for using same are described herein. A printer device may include a dedicated input that, when actuated, generates and sends a request to a computer for known data or a predetermined print job, e.g., schedule information from a personal information management (PIM) application. A scanner device may include another dedicated input that, when actuated, automatically scans a document fed to the device by the user and sends the scanned image to IM (or other) software on a computer, bypassing the need to manipulate the scanned image using scanner software. The device may be used with printed metapaper, which includes a barcode or other indicia identifying the metapaper and corresponds to a stored template image of the metapaper. When the metapaper is rescanned, the scan can be compared to the stored template information to identify changes and synchronize the changes with the IM software.

Abstract: A centralized view and management of stored variables for calculators and pieces of software emulating calculators is provided. Users can glance at the status bar and know what variables are stored. A single click then brings up a window within which a list of the stored variables and their values is shown. In this window users can clear individual variables or the entire variable list. Users can be reminded that their calculations contain stored variables by displaying the stored variable names in one or more different colors so that errors can be easily detected and corrected.

Abstract: Computer content navigation tools and associated methods are disclosed. One aspect of the invention is directed toward a computer-implemented method for providing content navigation information that includes displaying a navigation tool that proportionally represents a range of locations in a displayable content set. The method can further include displaying one or more anchors proximate to the navigation tool. Each anchor can correspond to a portion of the content set. The position of the anchors relative to the navigation tool can visually represent the displayable location of the corresponding portions relative to one another. In certain embodiments, the method can further include displaying a location marker proximate to the navigation tool and displaying at least one navigation arrow when a cursor is positioned proximate to a selected area of a display. When the cursor is no longer proximate to the selected area, the navigation arrow(s) can be removed.