Patents by Inventor Robert Distel

Robert Distel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED MICROORGANISMS FOR DETECTION OF DISEASED CELLS
    Publication number: 20240118283
    Abstract: The present invention relates to, inter alia, engineered microorganisms expressing (i) a surface protein, which specifically interacts cell membrane receptors that are specifically exposed to the luminal side of epithelial cells of diseased gastrointestinal tissue, and (ii) a secretable biomarker. The engineered bacteria of the present technology are useful for detecting diseased gastrointestinal tissue.
    Type: Application
    Filed: December 8, 2023
    Publication date: April 11, 2024
    Inventors: Jeffrey Wagner, Fred H. Mermelstein, Carl D. Novina, Robert Distel, Steven Neier, Barry Polisky
  • ENGINEERING MICROORGANISMS FOR DIAGNOSTIC IMAGING
    Publication number: 20230320591
    Abstract: The present invention relates to, inter alia, engineered bacteria expressing (i) a surface protein, which specifically interacts cell membrane receptors that are exposed to the luminal side of epithelial cells of diseased gastrointestinal tissue and/or epithelial tissue lining the bile duct, pancreatic duct, or common bile duct, etc., and (ii) a detection marker. The engineered bacteria of the present technology are useful for detecting diseased gastrointestinal tissue and/or epithelial tissue lining the bile duct, pancreatic duct, or common bile duct, etc.
    Type: Application
    Filed: June 1, 2021
    Publication date: October 12, 2023
    Inventors: Jeffrey WAGNER, Fred MERMELSTEIN, Carl NOVINA, Robert DISTEL, Steven NEIER, Barry POLISKY
  • Immunotherapy compositions and methods
    Patent number: 11225520
    Abstract: The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers and other immune disorders.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 18, 2022
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Carl Novina, Robert Distel, Alberto Nobili
  • COMPOSITIONS AND METHODS FOR TARGETED IMMUNOTHERAPY
    Publication number: 20210228699
    Abstract: The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers.
    Type: Application
    Filed: June 4, 2019
    Publication date: July 29, 2021
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Carl Novina, Robert Distel, Alberto Nobili, Steven Neier
  • IMMUNOTHERAPY COMPOSITIONS AND METHODS
    Publication number: 20190256597
    Abstract: The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers and other immune disorders.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 22, 2019
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Carl Novina, Robert Distel, Alberto Nobili
  • Method and apparatus for regenerating a soot filter of internal combustion engines
    Patent number: 4698966
    Abstract: A method for regenerating a soot filter of internal combustion engines, especially of diesel intenal combustion engines, and apparatus for carrying out the method in which a soot burning-off operation if initiated in predetemined intervals; the intervals are determined by an operating parameter of the internal combustion engine itself which results from the sum of a characteristic magnitude variable toward both sides.
    Type: Grant
    Filed: March 14, 1984
    Date of Patent: October 13, 1987
    Assignee: Bayerische Motoren Werke Aktiengesselschaft
    Inventors: Robert Distel, Peter Kugland
  • Burner and method for removal of accumulated soot on a soot filter in internal combustion engines
    Patent number: 4622811
    Abstract: A burner for cleaning accumulated soot from a soot filter associated with the exhaust of internal combustion engines, the burner is simple from a constructional viewpoint and especially effective with respect to initiation and maintenance of a soot-burning process in the soot filter. The burner includes a fuel nozzle, air nozzle, and glow plug arranged in a predetermined succession in the flow direction of the air introduced into the burner chamber. An especially intensive intermingling of the fuel-air mixture for the burner and/or for the soot filter is obtained by producing a turbulent flow by means of the air nozzle.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: November 18, 1986
    Assignee: Bayerische Motoren Werke AG
    Inventors: Robert Distel, Hans Groner, Peter Kugland