Abstract: The invention involves the coupling of compounds that can be bound by Haptocorrin (R-binder; Transcobalamin I; HC) to a target drug to improve pharmacokinetics, avoid undesirable side effects, and/or modify CNS access and localization. The pharmaceutical effect may be improved by conjugating the drug to haptocorrin binding substrate. This allows the conjugate to become bound to unsaturated haptocorrin in the blood, thereby protecting the drug from metabolism or excretion to increase protein half-life while not interfering with the efficacy of the protein drug. The conjugation may additionally prevent the drug from reaching the central nervous system or modify where the drug localizes and produces undesirable side effects such as nausea or hypophagia. Such a route also would prevent, in all case save for actual vitamin B12, binding by serum transcobalamin II (TCII), and thus not cause B12 deficiency with long term use.

Abstract: Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide sequences include regions that correspond to certain aspect of natural substrates and known agonists of the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2) in a single sequence.

Abstract: Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide sequences include regions that correspond to certain aspect of natural substrates and known agonists of the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2) in a single sequence.

Abstract: The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising IF and B12 conjugated to a peptide comprising a GLP-1 agonist. Advantageously, the composition may be delivered subcutaneously.

Abstract: The present invention relates to the digestion of peptides by pancreatic proteases and, more specifically, to compositions and methods for protecting against protease digestion.

Abstract: A dispensing device is selectively operable in a first mode of operation and a second mode of operation. The device comprises a base and a refill removably connectable with the base. The base comprises a first dispensing system and a first actuator communicably connected with the first dispensing system. The refill comprises a reservoir having a sidewall and an orifice. The first dispensing system is in fluid communication with the refill in the first mode of operation and the refill is disconnected from the base in the second mode of operation.

Abstract: A system for detecting cancer cells that targets the cubilin receptor for the vitamin B12 binding protein, intrinsic factor. A B12 conjugate and intrinsic factor is injected into the blood of a patient. The binding of intrinsic factor to cubilin will allow for receptor-mediated endocytosis and cellular internalization by cancerous cells, thereby allowing for detection via imaging or treatment.

Abstract: A method of dispensing a composition from a dispensing device includes use of a dispensing device. The dispensing device includes a base and a refill removably connectable with the base. The base has a first actuator and the refill having a second actuator. The method includes the steps of: activating the first actuator to dispense a quantity of a composition from the base; and disconnecting the refill from the base; and activating the second actuator to dispense the composition from the refill.

Abstract: A dispensing device is selectively operable in a first mode of operation and a second mode of operation. The device comprises a base and a refill removably connectable with the base. The base comprises a first dispensing system and a first actuator communicably connected with the first dispensing system. The refill comprises a reservoir having a sidewall and an orifice. The first dispensing system is in fluid communication with the refill in the first mode of operation and the refill is disconnected from the base in the second mode of operation.

Abstract: The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O(1.4H2O), [Ni(phen)2(H2P2O7)].8H2O(2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cu(phen)(H2O)(P2O7)][Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three compounds, {[Ni(phen)2]2(?-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(?-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(?-25P2O7)}.6MeOH (compound 13), (where phen is 1,10-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.

Abstract: A method of producing butanal by optimizing the growth of Streptomyces using cellulose as food source, overexpressing a key ‘gate’ enzyme in butyric acid/butyraldehyde production, and knocking out the isobutyryl-CoA synthase gene to shunt the pathway. Optionally, the produced butanal can be isolated and converted into butanol.

Abstract: An ophthalmic surgery kit includes a priming vessel defining a reservoir for holding a fluid, an auxiliary aspiration channel, an irrigation channel, a handpiece channel, and an ophthalmic surgical handpiece retained by the handpiece channel. The ophthalmic surgical handpiece includes a tip disposed within the reservoir. An auxiliary aspiration tube 15 retained by the auxiliary aspiration channel with a first end disposed within the reservoir. An irrigation tube first end is retained by the irrigation channel within the reservoir.

Abstract: A firearm butt stock includes a portable GPS unit having a display on a surface, and control buttons on adjacent surface/surfaces, and a butt stock including a cavity defined by sidewalls formed in one side thereof intermediate a rearward end and a forward end. The cavity receives the portable GPS unit therein with the display facing outwardly. Attachment apparatus removably secures the portable GPS unit within the cavity.

Abstract: A firearm butt stock includes a portable GPS unit having a display on a surface, and control buttons on adjacent surface/surfaces, and a butt stock including a cavity defined by sidewalls formed in one side thereof intermediate a rearward end and a forward end. The cavity receives the portable GPS unit therein with the display facing outwardly. Attachment apparatus removably secures the portable GPS unit within the cavity.

Abstract: A containment system for retaining spills in a body of water. The containment system remains in a submerged position for continuous monitoring and is deployed at the surface when activated for containment purposes. System aspects include a vertically retractable barrier configured to encircle at-risk infrastructure; a ballast system coupled to the barrier, the ballast system adapted to both submerge to a target depth upon receiving submerging signals and surface upon receiving surfacing signals; and a deployment control system in operative communication with the ballast system, the deployment control system configured to send submerging signals to employ the ballast system to submerge to a standby depth for extended periods of nominal operating conditions, and send surfacing signals to employ the ballast system to surface upon spill conditions; and may also include a self-propulsion system for containment system position management and an access gate for emergency vessel passage.

Abstract: An ophthalmic surgery kit includes a priming vessel defining a reservoir for holding a fluid, an auxiliary aspiration channel, an irrigation channel, a handpiece channel, and an ophthalmic surgical handpiece retained by the handpiece channel. The ophthalmic surgical handpiece includes a tip disposed within the reservoir. An auxiliary aspiration tube 15 retained by the auxiliary aspiration channel with a first end disposed within the reservoir. An irrigation tube first end is retained by the irrigation channel within the reservoir.

Abstract: A new isolate of Sporidiobolus johnsonii that is capable of producing over a significant percentage of CoQ10 upon the addition of para-hydroxy benzoic acid in stationary phase, and a method of obtaining CoQ10 from the S. johnsonii isolate which can be scaled up to industrial levels.

Abstract: A hitch assembly includes a hitch assembly frame. A tow bar includes a shaft having a first end pivotably attached to the hitch assembly frame and a coupling member attached to a second end of the shaft. A push plate is pivotably attached to the hitch assembly frame and defines a vertically aligned slot. The tow bar is movable within the vertically aligned slot. Such a hitch assembly may be used to operate machines, such as tractor scrapers, in a push-pull configuration.

Abstract: The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(?-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(?-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(?-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0?-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.

Abstract: The electromagnetic device for converting fuel based combustion engine to a hybrid or electric engine comprises an encasement with one or more electromagnets to replace a head gasket of a cyclinder of the fuel based combustion engine and a magnet connected to a top of a piston associated with the head gasket. The electromagnets in the encasement are powered by a battery and/or fuel cell. The magnet on the piston interacts with the electromagnets in the encasement to push and pull the piston within the cyclinder of the engine. The electromagnetic device further comprises a processor to control a sequence of push and pull of the piston within the cylinder of the engine by controlling the electromagnets in the encasement.