Abstract: A method and system for use therein for providing O2 and H2 gases directly to the soil proximal to the roots of plants via electrolysis is described. The method employs at least one electrolyzer disposed adjacent to, or inline with, the irrigation waterline of the plant grow operation to facilitate the introduction of the gases to the soil. A power source is used to provide the electrolytic conversion, and gases remain in a micro-bubbled form to flow through the waterline more easily to the plants where they are needed the most. A venturi is used to channel the dissolved gases in the waterline from the electrolyzer in embodiments having an external HyGrO unit. The inline embodiment electrolyzes the water without need of a venturi to reintroduce the gases to the waterline.

Abstract: A method and system for use therein for providing O2 and H2 gases directly to the soil proximal to the roots of plants, to harvested produce of plants, and to animals drinking supply via electrolysis is described. The method employs at least one electrolyzer disposed adjacent to, or inline with, the irrigation waterline of the plant grow operation or to the water supply waterline of the animals to facilitate the introduction of the gases to the soil or animals. A power source is used to provide the electrolytic conversion, and gases remain in a micro-bubbled form to flow through the waterline more easily to the plants where they are needed the most. A venturi may be used to channel the dissolved gases in the waterline from the electrolyzer in embodiments having an external unit. The preferred inline embodiment electrolyzes the water without need of a venturi to reintroduce the gases to the waterline.

Abstract: A method and system for use therein for providing O2 and H2 gases directly to the soil proximal to the roots of plants via electrolysis is described. The method employs at least one electrolyzer disposed adjacent to, or inline with, the irrigation waterline of the plant grow operation to facilitate the introduction of the gases to the soil. A power source is used to provide the electrolytic conversion, and gases remain in a micro-bubbled form to flow through the waterline more easily to the plants where they are needed the most. A venturi is used to channel the dissolved gases in the waterline from the electrolyzer in embodiments having an external HyGrO unit. The inline embodiment electrolyzes the water without need of a venturi to reintroduce the gases to the waterline.

Abstract: The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.

Abstract: The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.

Abstract: Anti-mesothelin antibodies and conjugates comprising such antibodies are disclosed herein as well as the use of such conjugates in the treatment of disease, such as cancer.

Abstract: The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates. The present disclosure also provides for anti-Nectin-4 antibodies or antigen binding fragments thereof and method for using the antibodies or antigen binding fragments thereof in treating cancer.

Abstract: The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates. The present disclosure also provides for anti-Nectin-4 antibodies or antigen binding fragments thereof and method for using the antibodies or antigen binding fragments thereof in treating cancer.

Abstract: The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates. The present disclosure also provides for anti-Nectin-4 antibodies or antigen binding fragments thereof and method for using the antibodies or antigen binding fragments thereof in treating cancer.

Abstract: Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGF?R1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.

Abstract: A method and system for use therein for providing O2 and H2 gases directly to the soil proximal to the roots of plants via electrolysis is described. The method employs at least one electrolyzer disposed adjacent to, or inline with, the irrigation waterline of the plant grow operation to facilitate the introduction of the gases to the soil. A power source is used to provide the electrolytic conversion, and gases remain in a micro-bubbled form to flow through the waterline more easily to the plants where they are needed the most. A venturi is used to channel the dissolved gases in the waterline from the electrolyzer in embodiments having an external HyGrO unit. The inline embodiment electrolyzes the water without need of a venturi to reintroduce the gases to the waterline.

Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.

Abstract: An aerosol medication delivery apparatus includes a fixed volume holding chamber which is constructed to allow for a uniformly mixed, concentrated bolus of medicated aerosol to be delivered with each breath. The device further includes a universal inlet, so that any standard small volume nebulizer, as well as any standard metered dose inhaler (MDI), may be utilized therewith. Also filtration can be added to address contaminated patient air and aerosol. A one-way valve is positioned in the patient mouthpiece, to help control the loss of aerosol, and thereby reduce waste.

Abstract: An aerosol medication delivery apparatus includes a fixed volume holding chamber which is constructed to allow for a uniformly mixed, concentrated bolus of medicated aerosol to be delivered with each breath. The device further includes a universal inlet, so that any standard small volume nebulizer, as well as any standard metered dose inhaler (MDI), may be utilized therewith. Also filtration can be added to address contaminated patient air and aerosol. A one-way valve is positioned in the patient mouthpiece, to help control the loss of aerosol, and thereby reduce waste.

Abstract: This invention relates to new human alpha-helix-containing polypeptides, to methods of making such polypeptides, to methods of using them to treat immunological conditions, and to methods of identifying compounds that alter alpha-helix-containing polypeptide activities.

Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.

Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

Abstract: The invention relates to the discovery that IMXP-888, a protein with homology to the FGF receptor family, is a proinflammatory cytokine. The invention encompasses therapeutic compositions of IMXP-888 polypeptides and antagonists, methods of use thereof, and screening methods.

Abstract: An aerosol medication delivery apparatus includes a fixed volume holding chamber which is constructed to allow for a uniformly mixed, concentrated bolus of medicated aerosol to be delivered with each breath. The device further includes a universal inlet, so that any standard small volume nebulizer, as well as any standard metered dose inhaler (MDI), may be utilized therewith. Also filtration can be added to address contaminated patient air and aerosol. A one-way valve is positioned in the patient mouthpiece, to help control the loss of aerosol, and thereby reduce waste.