Abstract: The present disclosure is directed to methods of immunization and methods for generating antibodies using compositions comprising cationic lipids and polynucleotide molecules, such as polyribonucleotide molecules, e.g., mRNA, which code for immunogens (e.g., a target protein or a fragment thereof).

Abstract: The present disclosure is directed to methods of immunization and methods for generating antibodies using compositions comprising cationic lipids and polynucleotide molecules, such as polyribonucleotide molecules, e.g., mRNA, which code for immunogens (e.g., a target protein or a fragment thereof).

Abstract: The present invention is directed to methods for making fermented beverages and other fermentation products including lactic acid and ethanol for fuel and the products produced therefrom.

Abstract: The present invention is directed to methods for making fermented beverages and other fermentation products including lactic acid and ethanol for fuel and the products produced therefrom.

Abstract: A system for providing an adaptive scenario-based user experience includes a scenario complexity determination unit that stores and disseminates scenarios in the form of individual lessons having a numeric scenario complexity level for teaching a learning objective. The system includes an instructor platform for controlling an operation of the scenario complexity determination unit, and a student platform for receiving the disseminated scenarios. The scenario complexity determination unit is encoded with instructions for selecting subsequent scenarios for dissemination to the student platform based on the received performance result.

Abstract: Methods of representing, recreating, and editing an audio composition involving: receiving at a digital audio workstation audio data that has been processed by an audio processing device; receiving at the digital audio workstation a set of metadata specifying a value for each of a plurality of settings of the audio processing device that define the state of the corresponding setting of the audio processing device when raw audio data received by the audio processing device was processed to generate the processed audio data; and storing the received processed audio data and the received set of metadata in an audio file, wherein the processed audio data is designated as audio information and the metadata is designated as settings data. The settings may be stored in a WAV or AIFF audio file, and may be retrieved, parsed, and applied to restore the audio processing device to the state corresponding to the retrieved audio.

Abstract: Methods of representing, recreating, and editing an audio composition involving: receiving at a digital audio workstation audio data that has been processed by an audio processing device; receiving at the digital audio workstation a set of metadata specifying a value for each of a plurality of settings of the audio processing device that define the state of the corresponding setting of the audio processing device when raw audio data received by the audio processing device was processed to generate the processed audio data; and storing the received processed audio data and the received set of metadata in an audio file, wherein the processed audio data is designated as audio information and the metadata is designated as settings data. The settings may be stored in a WAV or AIFF audio file, and may be retrieved, parsed, and applied to restore the audio processing device to the state corresponding to the retrieved audio.

Abstract: The present disclosure provides compounds having affinity for the 5HT6 receptor which are of the formula (I): wherein R1-R3 A, B, D, E, G, Q, and x are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: The present disclosure provides compounds having affinity for the 5HT6 receptor which are of the formula (I): wherein R1-R3 A, B, D, E, G, Q, and x are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, A, B, D, E, G, Ar, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: Compositions and methods for the treatment of a unipolar depression containing betaine, and folate. Formulations for oral administration optionally also contain L-methionine.

Abstract: The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.