Abstract: A compound having a structure of Formula I, provided. In the compounds, each of X1 to X12 is C or N; R is not hydrogen or deuterium; each RA and RB is hydrogen or a General Substituent defined herein; a HOMO level of the compound is greater than ?5.56 eV; and the compound does not comprise a group selected from indolocarbazole, acridine, phenoxazine, phenothiazine, 10,10-diphenyl-5,10-dihydrodibenzo[b,e][1,4]azasiline (dibenzoazasiline), inbimbim, 3,9? bicarbazole, and 3,3? bicarbazole moiety. Formulations, OLEDs, and consumer products containing the compound are also provided.

Abstract: Provided are organic compounds comprising a boron atom which is part of two 6-membered rings which are fused together and to which at least three further 6-membered aromatic rings are fused. Also provided are formulations comprising these organic compounds. Further provided are organic light emitting devices (OLEDs) as well as related consumer products that utilize these organic compounds.

Abstract: A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture.

Abstract: A shoe sole for an article of footwear is described herein. The shoe sole extends in a longitudinal direction from a heel region, through a midfoot region, to a forefoot region. The sole includes a midsole and an outsole. The midsole has an upper surface for attachment to at least one of an insole and a shoe upper, and a lower surface disposed opposite the upper surface. The midsole includes a forefoot cushioning element, a midfoot cushioning element, and a heel cushioning element. The outsole is disposed along the lower surface of the midsole and defines a ground-contacting surface of the sole. The sole has an upwardly convex bottom profile such that an impact region of the sole is defined within the midfoot region, and the midfoot cushioning element is disposed within the midfoot region and directly above the impact region of the sole.

Abstract: Drug delivery devices are provided that are configured to release drug following passive or active activation of the device protecting the drug contained therein. In one aspect, the device may be configured to release a drug following selective application of light irradiation to the device. In another aspect, the device is configured to a release drug following degradation of at least a part of the device body that is formed, for example, from a bioerodible, hermetic material. An exemplary bioerodible, hermetic material is a biodegradable glass. Still other aspects provide for release of a drug upon a combination of both passive and active activation of the device.

Abstract: A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture.

Abstract: Devices and methods are provided for selectively delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug unit contained in the enclosed reservoir. The at least one drug unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site.

Abstract: Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.

Abstract: A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.

Abstract: The present application is directed to devices. The device may used for connecting a closed receptacle and a container, such as a syringe.

Abstract: Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.

Abstract: The present invention is directed to a vibrating band comprising a belt-like O-ring, a housing with a vibrating device contained within the housing. The vibrating device comprises a vibrating motor, one or more batteries and a touch or push switch. The vibrating band can be used by a male user to increase stimulation for both the male and his partner during sexual intercourse.

Abstract: Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.

Abstract: A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.

Abstract: A brain implant system consistent with embodiments of the present invention includes an electrode array having a plurality of electrodes for sensing neuron signals. A method for manufacturing the electrode array includes machining a piece of an electrically conductive substance to create a plurality of electrodes extending from a base member. Each electrode also has a corresponding base section. A nonconductive layer is provided around at least a portion of the base section of each electrode to support the plurality of electrodes. The base section of the electrodes are then cut to separate the base member from the plurality of electrodes supported by the nonconductive support layer. The present invention also includes a complete brain implant system using the above electrode array.

Abstract: An apparatus is provided to hold and orient an implant during a medical procedure and includes an elongated member having an upper member and a lower member with a formed end. A biasing member is operatively positioned between the upper member and lower member and supplies a biasing force to the lower member. A ball joint is provided that includes a ball, and the ball joint accepts the formed end of the lower member. A biasing force is provided by the biasing member to cause the formed end of the lower member to contact the ball. A translation mechanism is used to move the upper member in a first linear direction toward the lower member to cause the formed end of the lower member to lock the ball of the ball joint and, thus, lock the ball joint and orient the ball of the ball joint in a desired position.

Abstract: A drug injector includes a chamber for holding a drug to be injected into a biological body, and an nozzle through which the drug is injected. A piston is positioned in the chamber, and an actuator is coupled to the piston. The actuator includes a member that contracts when heated. In some embodiments, heating of the member is induced by applying a potential to the member. The actuator moves the piston towards the nozzle when the member is heated to expel the drug out of the chamber through the nozzle. The drug injector can include a sensor for measuring properties, such as stiffness, of the outer layer of the body. Further, the drug injector can adjust the piston movement based on the sensed properties. Alternatively, the sensor can be used with other medical devices, such as microneedle transport devices.