Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: Provided herein are devices, systems, and methods for measuring the presence of an analyte of interest in a sample. Certain embodiments of the present disclosure are related to culture measurement systems that include a culture vial and a sensor, wherein the sensor is a pH sensor, a responsive label, or an indicator compound, such that the sensor is incorporated into the culture vial for measurement of the pH of the sample.

Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: A test strip reader is provided with an optical mouse integrated circuit sensor that reads the test line, reference line and control line of a lateral flow assay strip by light absorption and determines the position of the test strip beneath the image on the integrated circuit board using digital signal processing algorithms. The digital signal processing algorithms process the imaged surface at a very high rate (e.g., 1500 frames per second) to determine the direction and speed of movement of the lateral strip with respect to the reader optics and image capture components. The sensor outputs this position information in a quadrature pattern format. A microcontroller uses the known position of the strip with respect to the reader to calculate the optical absorption of each colored reagent line, and the diagnostic significance (i.e., either qualitative or quantitative) of the test strip.

Abstract: A diagnostic microbiological testing system and method for microorganism identification (ID) and antimicrobial susceptibility determinations (AST). The system includes multiple-well test panels capable of performing ID and AST testing on the same test panel. Each test panel is inoculated with reagents, broth-suspended organisms, and placed into the instrument system. The instrument system includes a rotating carousel for incubation and indexing, multiple light sources each emitting different wavelength light, precision calorimetric and fluorometric detection, barcode test panel tracking and a control processor for making determinations based on measured test data. One light source includes a plurality of LEDs arranged in a linear array. Each of the LEDs' junction currents are controllable to produce a predetermined illumination profile.

Abstract: A medication for burns and wounds comprising beeswax in combination with butter and with, in most application, rosin, for providing immediate relief of pain and hastening the scabbing process. For medications with rosin, the formulation comprise 7-14% rosin, 10-50% beeswax and 50-70% butter preferably at a ratio of one part rosin, 2-4 parts beeswax, and 10-12 parts unsalted butter. All ingredients are natural and commercially available. The medication is stable at room temperature and is observed to increase its effectiveness or efficacy with storage.

Abstract: A diagnostic microbiological testing system and method for microorganism identification (ID) and antimicrobial susceptibility determinations (AST). The system includes multiple-well test panels capable of performing ID and AST testing on the same test panel. Each test panel is inoculated with reagents, broth-suspended organisms, and placed into the instrument system. The instrument system includes a rotating carousel for incubation and indexing, multiple light sources each emitting different wavelength light, precision calorimetric and fluorometric detection, barcode test panel tracking and a control processor for making determinations based on measured test data. One light source includes a plurality of LEDs arranged in a linear array. Each of the LEDs' junction currents are controllable to produce a predetermined illumination profile.

Abstract: A diagnostic microbiological testing system and method for microorganism identification (ID) and antimicrobial susceptibility determinations (AST). The system includes multiple-well test panels capable of performing ID and AST testing on the same test panel. Each test panel is inoculated with reagents, broth-suspended organisms, and placed into the instrument system. The instrument system includes a rotating carousel for incubation and indexing, multiple light sources each emitting different wavelength light, precision calorimetric and fluorometric detection, barcode test panel tracking and a control processor for making determinations based on measured test data. One light source includes a plurality of LEDs arranged in a linear array. Each of the LEDs' junction currents are controllable to produce a predetermined illumination profile.

Abstract: A distributed network monitor system distributes the network monitoring function among each of the nodes of a multiple network system, such that monitor software resident in each node is responsible for providing status information about that node and its communications links. At predetermined monitoring intervals, a circulating status table (CST) (FIG. 4) is circulated to all of the on-line nodes, with each node updating the CST with its link and status information. The monitor software (FIG. 1) includes a servicer task (22), a node monitor task (24), and a packet manager task (26), with intertask data transfers being implemented through a monitor region (28) in memory. In addition to link and node status information, the CST includes information about links that are in an intermittent condition (i.e., links with significantly degraded statistical performance).

Abstract: A vessel for carrying liquids or other loose materials is provided comprising a generally pentagonal, hollow body. The body of the vessel has an open top, convenient pouring spouts, and supportive handle which is an integral part of the lower half of one side of the body. The inner cavity of the body of the vessel is formed into a ledge at the top of the handle which, in conjuction with the notched spout directly opposite, provides an excellent paint brush holder. Three ridges in the bottom aid in cleaning one's paintbrush like a wash-board and serve as a place to grip with one's fingers when holding the bucket.It is designed to be light-weight, comfortable, and versatile. It is specially designed as a paint bucket by virtue of its built-in brush holder, the ease with which it can be cleaned, and its pouring spouts.