Patents by Inventor Robert E. Babine

Robert E. Babine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and Methods For Treatment of Thrombosis
    Publication number: 20080146811
    Abstract: The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.
    Type: Application
    Filed: July 22, 2005
    Publication date: June 19, 2008
    Inventors: Hongfeng Deng, Jian Lin, Zihong Guo, Harold V. Meyers, Sherin S. Abdel-Meguid, Robert E. Babine
  • Compounds and methods for treatment of thrombosis
    Patent number: 7217794
    Abstract: The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: May 15, 2007
    Assignee: Daiamed, Inc.
    Inventors: Sherin S. Abdel-Meguid, Robert E. Babine, Hongfeng Deng, Lei Jin, Jian Lin, Scott R. Magee, Harold V. Meyers, Pramod Pandey, Michael J. Rynkiewicz, David T. Weaver, Zihong Gho, Thomas D. Bannister
  • Antipicornaviral compounds and methods for their use and preparation
    Patent number: 6362166
    Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 26, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Peter S. Dragovich, Thomas J. Prins, Siegfried H. Reich, Thomas L. Little, Jr., Ethel S. Littlefield, Joseph T. Marakovits, Robert E. Babine, Ted M. Bleckman
  • Antipicornaviral compounds and methods for their use and preparation
    Patent number: 6214799
    Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
    Type: Grant
    Filed: January 7, 1999
    Date of Patent: April 10, 2001
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Peter S. Dragovich, Thomas J. Prins, Siegfried H. Reich, Thomas L. Little, Jr., Ethel S. Littlefield, Joseph T. Marakovits, Robert E. Babine, Ted M. Bleckman
  • Antipicornaviral compounds and methods for their use and preparation
    Patent number: 5962487
    Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: October 5, 1999
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Peter S. Dragovich, Thomas J. Prins, Ethel S. Littlefield, Joseph T. Marakovits, Robert E. Babine
  • Antipicornaviral compounds and methods for their use and preparation
    Patent number: 5856530
    Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: January 5, 1999
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Peter S. Dragovich, Thomas J. Prins, Siegfried H. Reich, Thomas L. Little, Jr., Ethel S. Littlefield, Joseph T. Marakovits, Robert E. Babine, Ted M. Bleckman
  • Retroviral protease inhibitors
    Patent number: 5430150
    Abstract: Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Robert E. Babine, Nan Zhang, Steven R. Schow, Allan Wissner