Abstract: Compositions and methods for mitigating a pathology following brain trauma or at least a portion of a cascade of a pathology associated therewith, including compositions and methods for treating concussion or preventing the onset of anecrotic cell death in neurons. Exemplary compositions for treating concussion include an active compound comprising one or more of: phenserine, a phenserine metabolite, a phenserine prodrug, or combinations thereof; and one or more pharmaceutically acceptable excipients. The one or more excipients can be combined with the active compound to form an extended, controlled-release medicament that delivers a therapeutic concentration of the active compound over a period of time.

Abstract: Compositions and methods for mitigating a pathology following brain trauma or at least a portion of a cascade of a pathology associated therewith, including compositions and methods for treating concussion or preventing the onset of anecrotic cell death in neurons. Exemplary compositions for treating concussion include an active compound comprising one or more of: phenserine, a phenserine metabolite, a phenserine prodrug, or combinations thereof; and one or more pharmaceutically acceptable excipients. The one or more excipients can be combined with the active compound to form an extended, controlled-release medicament that delivers a therapeutic concentration of the active compound over a period of time.

Abstract: Compositions and methods for mitigating a pathology following brain trauma or at least a portion of a cascade of a pathology associated therewith, including compositions and methods for treating concussion or preventing the onset of anecrotic cell death in neurons. Exemplary compositions for treating concussion include an active compound comprising one or more of: phenserine, a phenserine metabolite, a phenserine prodrug, or combinations thereof; and one or more pharmaceutically acceptable excipients. The one or more excipients can be combined with the active compound to form an extended, controlled-release medicament that delivers a therapeutic concentration of the active compound over a period of time.

Abstract: Using the method of invention health care system managers, government authorities, insurers, health providers, can use devices, tests, methods of assessment, software programming or hardware programming or other procedures for determining the health or health related status of a person to reach sufficient precision and certainty in clinical examination and test measurements that the true health status of an individual can be described, differentiated from the measurement error components in each examination and test result and the course of the measurements interpreted meaningfully as part of a physician or patient or member of the public seeking well-being and health adopting a prescribed or self prescribed plan for monitoring health and achieving desired health goals and as part of health care system managers, government authorities, insurers, health providers providing improved controls over the quality and costs of health care.

Abstract: A low sidestream smoke cigarette comprises a conventional tobacco rod and a non-combustible treatment material for the rod. The treatment material has a porosity less than about 200 Coresta units and a sidestream smoke treatment composition. The treatment composition comprises, in combination, an oxygen storage and donor metal oxide oxidation catalyst and an essentially non-combustible finely divided porous particulate adjunct for said catalyst. In addition, the invention provides a low sidestream smoke cigarette unit that comprises a cigarette with conventional cigarette paper surrounding a conventional tobacco rod and a non-combustible treatment material surrounding and being substantially in contact with the conventional cigarette paper.

Abstract: A cigarette sidestream smoke treatment material made from a sheet of non-combustible active components provides a porous structure capable of treating sidestream smoke. The treatment material, as used in combination with a cigarette, provides a low sidestream smoke emitting cigarette unit. The material has a porosity which encourages a conventional free-burn rate of a conventional cigarette. The material may comprise a sorbent capable of sorbing components of the sidestream smoke, and an oxygen storage component which releases oxygen at free-burn rate temperatures to ensure that conventional free-burn rate is maintained and to enhance the oxidation treatment of the adsorbed non-aqueous components. Preferably, an oxidation catalyst is included in the material and most desirably the oxygen storage component may also function as the oxidation catalyst. Particularly preferred materials which perform the dual function are oxides of cerium.

Abstract: This invention relates to a method for improving memory and accompanying symptoms in patients with Alzheimer's disease and related disorders of memory. The method includes the steps of dosing a patient with 2,2-dichlorovinyl dimethyl phosphate sometimes referred to as dichlorvos or DDVP, or a precursor thereof maintaining said dosage at a level and over a period of time sufficient to create a concentration of DDVP in the brain whereby memory improvement occurs. A satisfactory precursor for this method is 2,2,2-trichloro-1-hydroxyethyl dimethyl phosphate sometimes referred to as metrifonate and 1,2-dibromo, 2-dichlorvoethyl dimethyl phosphate sometimes referred to as naled. Other precursors are also useful.