Patent number: 6465486
Abstract: Certain imidazo pyridines/quinolines of the formula:
where
n is 0, 1, 2;
X is independently selected from the group consisting of C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2, nitro, and two adjacent X may be fused to form the moiety:
whereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed;
Y is independently selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, trifluoromethyl and phenyl; and
Z is independently selected from the group consisting of hydroxy, C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2 and nitro;
are &agr;2-adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.
Type:
Grant
Filed:
March 10, 2000
Date of Patent:
October 15, 2002
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
Ellen W. Baxter, Robert E. Boyd, John R. Carson, Michele C. Jetter, Allen B. Reitz
