Patents by Inventor Robert E. Briggs
Robert E. Briggs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6573093Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: June 3, 2003Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6495145Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: December 17, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20020150584Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: January 25, 2002Publication date: October 17, 2002Applicant: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20020086413Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: October 19, 2001Publication date: July 4, 2002Inventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20020039589Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: October 19, 2001Publication date: April 4, 2002Inventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6331303Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: September 25, 1998Date of Patent: December 18, 2001Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20010018055Abstract: Virulence factor mutants of Pasteurellaceae provide excellent safety and efficacy when used as vaccines in mammals, especially ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: December 15, 2000Publication date: August 30, 2001Inventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5849305Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: December 15, 1998Assignees: The United States of America as represented by the Secretary of the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5840556Abstract: Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extrachromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis.A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.Type: GrantFiled: December 19, 1996Date of Patent: November 24, 1998Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5824525Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: October 20, 1998Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5733780Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: March 31, 1998Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology and Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5693777Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: December 2, 1997Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5683900Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: November 4, 1997Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5587305Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: December 6, 1993Date of Patent: December 24, 1996Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 4134198Abstract: A grip for the handle of a hand-held implement that, in as-produced form, is comprised of a thin walled tubular member open at one end and a boot integral with the tubular member that closes its other end. The grip's average internal girth along its longitudinal axis, as produced, is substantially less than the average external girth of the implement's handle portion to be covered by the grip along that handle portion's longitudinal axis. The grip, which may have a novel exterior gripping surface, is produced by dipping a male mandrel into an elastomeric latex and, thereafter, curing the latex skin formed on the mandrel prior to stripping of the grip from the mandrel. The grip is installed on an implement's handle by creating a pressure differential between the interior and exterior of the grip, thereby causing the grip to stretch radially outward from its longitudinal axis.Type: GrantFiled: January 3, 1977Date of Patent: January 16, 1979Assignee: `TOTES`, IncorporatedInventor: Robert E. Briggs
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Patent number: 4016640Abstract: A grip for the handle of a hand-held implement that, in as-produced form, is comprised of a thin walled tubular member open at one end and a boot integral with the tubular member that closes its other end. The grip's average internal girth along its longitudinal axis, as produced, is substantially less than the average external girth of the implement's handle portion to be covered by the grip along that handle portion's longitudinal axis. The grip, which may have a novel exterior gripping surface, is produced by dipping a male mandrel into an elastomeric latex and, thereafter, curing the latex skin formed on the mandrel prior to stripping of the grip from the mandrel. The grip is installed on an implement's handle by creating a pressure differential between the interior and exterior of the grip, thereby causing the grip to stretch radially outward from its longitudinal axis.Type: GrantFiled: August 27, 1975Date of Patent: April 12, 1977Assignee: `Totes` IncorporatedInventor: Robert E. Briggs
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Patent number: RE38028Abstract: Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extra-chromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis. A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.Type: GrantFiled: November 21, 2000Date of Patent: March 11, 2003Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Robert E. Briggs, Fred M. Tatum