Patents by Inventor Robert E. Burgeson

Robert E. Burgeson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • B1k chain of laminin and methods of use
    Patent number: 7273929
    Abstract: Recombinant laminin B1k and fragments thereof.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: September 25, 2007
    Assignees: The General Hospital Corporation, The State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Health Sciences University
    Inventors: Robert E. Burgeson, David Wolfe Wagman
  • B1k chain of laminin and methods of use
    Patent number: 6916631
    Abstract: Antibodies directed against laminin B1k are provided.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: July 12, 2005
    Assignee: The General Hospital Corporation
    Inventors: Robert E. Burgeson, David Wolfe Wagman
  • B1k chain of laminin and methods of use
    Publication number: 20040208881
    Abstract: Antibodies directed against laiminin B1k are provided.
    Type: Application
    Filed: May 7, 2004
    Publication date: October 21, 2004
    Applicants: The General Hospital Corporation, a Massachusetts corporation, The State Board of Higher Education on behalf of Oregon Health Sciences University
    Inventors: Robert E. Burgeson, David Wolfe Wagman
  • Laminin 5, 13 and 14 and uses thereof
    Patent number: 6693169
    Abstract: The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. The present invention also features using a preparation of laminin 5 to treat neural disorders, especially disorders associated with retina.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: February 17, 2004
    Assignee: The General Hospital Corporation
    Inventors: William J. Brunken, Richard R. Libby, Dale D. Hunter, Robert E. Burgeson
  • B1k chain of laminin and methods of use
    Publication number: 20040023856
    Abstract: Recombinant laminin B1k and fragments thereof.
    Type: Application
    Filed: May 22, 2003
    Publication date: February 5, 2004
    Applicants: The General Hospital Corporation, a Massachusetts corporation, State Board of Higher Education on behalf of Oregon Health Sciences University
    Inventors: Robert E. Burgeson, David Wolfe Wagman
  • Laminins and uses thereof
    Patent number: 6682911
    Abstract: The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant preparation of laminin 12 which includes an &agr;2 subunit, &bgr;1 subunit and a &ggr;3 subunit.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: January 27, 2004
    Assignee: The General Hospital Corporation
    Inventors: Robert E. Burgeson, Marie-France Champliaud, Pamela Olson, Manuel Koch, William Brunken
  • Laminin 5 and the formation of basement membrane structure
    Patent number: 6153593
    Abstract: The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: November 28, 2000
    Assignees: The General Hospital Corporation, Shiseido Co., Ltd., University School of Medicine
    Inventors: Robert E. Burgeson, Makoto Tsunenaga, Satoshi Amano, Toshio Nishiyama, Eijiro Adachi, Nobuyuji Shioya
  • Products and methods for improving keratinocyte adhesion to the dermis
    Patent number: 6133236
    Abstract: Improving adhesion of epidermis to an underlying dermal substrate including the step of providing an amount of purified kalinin between the epidermis and dermal substrate wherein the kalinin provides adhesion between the human dermis and epidermis wherein said kalinin is a trimeric molecule having the following three nonidentical chains: a chain which includes the BM165 epitope, either a 155 kilodalton chain or a 105 kilodalton chain, and a 140 kilodalton chain.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: October 17, 2000
    Assignee: Oregon Health Sciences University
    Inventors: Robert E. Burgeson, Gregory P. Lunstrum, Patricia Rouselle, Douglas R. Keene, M. Peter Marinkovich
  • B1k chain of laminin and methods of use
    Patent number: 5914317
    Abstract: Recombinant laminin B1k and fragments thereof.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: June 22, 1999
    Assignees: The General Hospital Corporation, The State of Oregon Acting By & Thru The State Board . . .
    Inventors: Robert E. Burgeson, David Wolfe Wagman
  • Products and methods for improving keratinocyte adhesion to the dermis
    Patent number: 5770562
    Abstract: The isolated proteins kalinin and k-laminin are disclosed to provide adhesion between epidermal keratinocytes and the underlying dermis. Purified kalinin localizes to the anchoring filaments of basement membranes of human subepithelial skin, trachea, esophagus, cornea and amnion when such areas are probed with BM165 monoclonal antibody after localization. The protein has a molecular weight of approximately 410-495 kDa and exists in a cell-associated form (about 495 kDa) and two medium-associated forms (about 460 and 410 kDa, respectively). The BM165 epitope is located on the 165-kDa and 200 kDa subunits. Kalinin has a rotary-shadow image revealing an asymmetric rod 107-nm long having two globules at a first end and a single globule at an opposing end. The k-laminin adhesion molecule is an isolated heterotrimeric laminin variant that has a molecular weight of about 650 kDa and separates on western blots into first and second fragments that are similar to the B1 and B2 fragments of laminin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 23, 1998
    Assignee: Oregon Health Sciences University
    Inventors: Robert E. Burgeson, Gregory P. Lunstrum, Patricia Rousselle, Douglas R. Keene, M. Peter Marinkovich
  • B1k chain of laminin and methods of use
    Patent number: 5610031
    Abstract: Recombinant laminin B1k and fragments thereof.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: March 11, 1997
    Assignees: The General Hospital Corporation, The State of Oregon Acting By & Thru the State Board . . .
    Inventors: Robert E. Burgeson, David W. Wagman
  • KS-laminin and methods of use
    Patent number: 5580960
    Abstract: KS-laminin and a KS-laminin-kalinin adduct are disclosed. The molecules of the invention are useful for promoting the adhesion of keratinocytes to a substrate.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: December 3, 1996
    Assignee: The General Hospital Corporation
    Inventors: Robert E. Burgeson, Marie-France Champliaud