Patents by Inventor Robert E. Garfield
Robert E. Garfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11058900Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied transabdominally and directed at the cervix.Type: GrantFiled: November 22, 2017Date of Patent: July 13, 2021Assignees: Dignity Health, Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Bruce C. Towe, Robert E. Garfield, Shao-Qing Shi
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Publication number: 20200163976Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: ApplicationFiled: January 30, 2020Publication date: May 28, 2020Inventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Patent number: 10555955Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: GrantFiled: September 15, 2017Date of Patent: February 11, 2020Assignee: Dignity HealthInventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Patent number: 10328254Abstract: Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.Type: GrantFiled: October 25, 2016Date of Patent: June 25, 2019Assignee: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Publication number: 20180093112Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied transabdominally and directed at the cervix.Type: ApplicationFiled: November 22, 2017Publication date: April 5, 2018Inventors: Bruce C. Towe, Robert E. Garfield, Shao-Qing Shi
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Patent number: 9872983Abstract: Systems and methods for producing cervical ripening in a pregnant patient. The method includes generating an electrical stimulation current between about 0.01 milliamperes and about 6 milliamperes using a current unit, coupling an electrode probe to the current unit, and inserting the electrode probe transvaginally so that at least one electrode of the electrode probe is in contact with the patient's cervix. The method also includes applying the electrical stimulation current from the current unit through the electrode probe and the at least one electrode to the patient's cervix to produce ripening of the patient's cervix.Type: GrantFiled: April 22, 2016Date of Patent: January 23, 2018Assignee: Dignity HealthInventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi, William Maner
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Publication number: 20180000838Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: ApplicationFiled: September 15, 2017Publication date: January 4, 2018Inventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Patent number: 9731120Abstract: Some embodiments of the invention provide a system and method for treating insufficient uterine contractions after labor and delivery. The system includes a control module and a current source controlled by the control module to produce stimulating current at a frequency greater than or equal to about 5.0 Hertz. The system also includes one or more stimulation electrodes to provide the stimulating current to the patient in order for the patient to produce tonic uterine contractions.Type: GrantFiled: November 5, 2013Date of Patent: August 15, 2017Assignee: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Patent number: 9572972Abstract: Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.Type: GrantFiled: January 29, 2015Date of Patent: February 21, 2017Assignee: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Publication number: 20170036011Abstract: Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.Type: ApplicationFiled: October 25, 2016Publication date: February 9, 2017Inventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Publication number: 20160235979Abstract: Systems and methods for producing cervical ripening in a pregnant patient. The method includes generating an electrical stimulation current between about 0.01 milliamperes and about 6 milliamperes using a current unit, coupling an electrode probe to the current unit, and inserting the electrode probe transvaginally so that at least one electrode of the electrode probe is in contact with the patient's cervix. The method also includes applying the electrical stimulation current from the current unit through the electrode probe and the at least one electrode to the patient's cervix to produce ripening of the patient's cervix.Type: ApplicationFiled: April 22, 2016Publication date: August 18, 2016Inventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi, William Maner
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Publication number: 20160175325Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: ApplicationFiled: January 22, 2016Publication date: June 23, 2016Applicant: DIGNITY HEALTHInventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Patent number: 9271991Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: GrantFiled: October 27, 2011Date of Patent: March 1, 2016Assignee: Dignity HealthInventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Publication number: 20150306429Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied trans-abdominally and directed at the cervix. Ultrasound energy is widely used in medical applications such as diagnostic imaging, therapeutic heating and noninvasive surgery.Type: ApplicationFiled: December 10, 2013Publication date: October 29, 2015Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Bruce C. Towe, Robert E. Garfield, Shao-Qing Shi
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Publication number: 20150165190Abstract: Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.Type: ApplicationFiled: January 29, 2015Publication date: June 18, 2015Applicant: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Publication number: 20150127017Abstract: Systems and methods for producing cervical ripening in a pregnant patient. The method includes generating an electrical stimulation current between about 0.01 milliamperes and about 6 milliamperes using a current unit, coupling an electrode probe to the current unit, and inserting the electrode probe transvaginally so that at least one electrode of the electrode probe is in contact with the patient's cervix. The method also includes applying the electrical stimulation current from the current unit through the electrode probe and the at least one electrode to the patient's cervix to produce ripening of the patient's cervix.Type: ApplicationFiled: May 20, 2013Publication date: May 7, 2015Inventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi, William Maner
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Patent number: 8972028Abstract: Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.Type: GrantFiled: October 26, 2011Date of Patent: March 3, 2015Assignee: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Publication number: 20140141102Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.Type: ApplicationFiled: October 27, 2011Publication date: May 22, 2014Applicant: DIGNITY HEALTHInventors: Robert E. Garfield, Shao-Qing Shi, Leili Shi
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Publication number: 20140058473Abstract: Some embodiments of the invention provide a system and method for treating insufficient uterine contractions after labor and delivery. The system includes a control module and a current source controlled by the control module to produce stimulating current at a frequency greater than or equal to about 5.0 Hertz. The system also includes one or more stimulation electrodes to provide the stimulating current to the patient in order for the patient to produce tonic uterine contractions.Type: ApplicationFiled: November 5, 2013Publication date: February 27, 2014Inventors: Robert E. Garfield, Harvey Carp, William L. Maner
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Patent number: 8606371Abstract: Some embodiments of the invention provide a system and method for treating insufficient uterine contractions after labor and delivery. The system includes a control module and a current source controlled by the control module to produce stimulating current at a frequency greater than or equal to about 5.0 Hertz. The system also includes one or more stimulation electrodes to provide the stimulating current to the patient in order for the patient to produce tonic uterine contractions.Type: GrantFiled: April 7, 2010Date of Patent: December 10, 2013Assignee: Dignity HealthInventors: Robert E. Garfield, Harvey Carp, William L. Maner