Abstract: A system determines absolute speed of a moving object. In AM, time of flight data over a time period is processed to determine ranges between the system and the moving object. The system performs linear regression analysis on the collected ranges to calculate the radial velocity. The system measures angular swivel rate of the system to determine tangential velocity. From the radial velocity and tangential velocity, the absolute speed can be calculated by taking the square root of the addition of the square of the radial velocity and square of the tangential velocity. In MM, the system calculates object distance, i.e. distance in the direction of travel, by subtracting the square of a pre-determined perpendicular distance L, perpendicular to the direction of travel, from a square of line-of-sight distance R, and taking square root of the result. Absolute speed is determined by calculating the slope of modified linear regression curve-fit.

Abstract: A system determines absolute speed of a moving object. In AM, time of flight data over a time period is processed to determine ranges between the system and the moving object. The system performs linear regression analysis on the collected ranges to calculate the radial velocity. The system measures angular swivel rate of the system to determine tangential velocity. From the radial velocity and tangential velocity, the absolute speed can be calculated by taking the square root of the addition of the square of the radial velocity and square of the tangential velocity. In MM, the system calculates object distance, i.e. distance in the direction of travel, by subtracting the square of a pre-determined perpendicular distance L, perpendicular to the direction of travel, from a square of line-of-sight distance R, and taking square root of the result. Absolute speed is determined by calculating the slope of modified linear regression curve-fit.

Abstract: A multipurpose tool including a frame defining a first edge, a second edge and a third edge joined one to the other at the ends thereof to form an enclosure. The tool including a center portion coupled to each of the first, second and third edges, and having a first tool coupled to the first edge, a second tool coupled to the second edge; and a third tool coupled to the third edge. A grip being attached to the center portion. A multi-purpose tool kit is provided comprising a multi-purpose tool and a plurality of pads, each pad being configured to removably attach to an edge of the multi-purpose tool.

Abstract: A multipurpose tool including a frame defining a first edge, a second edge and a third edge joined one to the other at the ends thereof to form an enclosure. The tool including a center portion coupled to each of the first, second and third edges, and having a first tool coupled to the first edge, a second tool coupled to the second edge; and a third tool coupled to the third edge. A grip being attached to the center portion. A multi-purpose tool kit is provided comprising a multi-purpose tool and a plurality of pads, each pad being configured to removably attach to an edge of the multi-purpose tool.

Abstract: Reduced-immunogenic fusion compounds are disclosed. The fusion compounds of the invention comprise immunogenic compounds linked to auto-antigenic sequences which render the compound less immunogenic. In addition, a method of reducing the immunogenicity of an immunogenic compound is disclosed. The method comprises linking an auto-antigenic sequence to an otherwise immunogenic compound. Recombinant nucleotide sequences encoding auto-antigenic sequences are also disclosed.

Abstract: Methods for sustained delivery of a therapeutic agent to the circulation of a patient are disclosed. Also disclosed are methods of preparing bioconjugates for sustained delivery of a therapeutic agent to the circulation of a patient.

Abstract: Indirect method of detecting elastase-modified or cleaved, antithrombin (ATx) in the presence of intact antithrombin (AT-III). The inventive method includes a modified ELISA using a detergent to alter the intact AT-III. Cleaved AT-III is generated in human plasma, then an ELISA is performed in the presence of a detergent.

Abstract: A pressure proof reactor vessel and the method of making such vessel wherein the vessel has a cylindrical one-piece outer wall and a cylindrical one-piece cylindrical inner liner, which liner has a smooth continuous interior surface spaced radially inwardly from the outer wall and concentric thereto. The inner cylindrical wall is formed from a one-piece material with its radial thickness being substantially less than the radial thickness of the outer cylindrical wall. Support means in the form of a spiral is positioned in said space between the cylindrical outer wall and the cylindrical inner liner defining a pathway for the flow of coolant between the outer wall and the inner wall. The support spiral is secured to the outer surface of the one-piece cylindrical inner liner prior to assembling of the inner liner to the outer cylindrical one-piece outer wall.

Abstract: Preparation of active therapeutic proteins comprising two essential steps. In the first step an active protein source is treated under conditions sufficient to inactivate any viruses present (e.g. via heat or chemical treatment). In the second step, the treated active protein source of moderate purity is then treated under conditions sufficient to remove impurities as well as denatured (once active) proteins resulting from the viral inactivation step. In an illustrative embodiment, a biologically active protein such as antithrombin is treated under conditions sufficient to assure viral inactivation and minimal antithrombin deactivation. After the viral inactivation, the antithrombin is contacted with immobilized heparin to complex only the active antithrombin which is then eluted by known means and processed further (e.g., to include desired excipients and then freeze dried).

Abstract: There is disclosed a non-carbohydrate sulfated matrix and the use thereof to isolate and purify blood clotting factors and other blood proteins by a procedure involving the adsorption of at least one of such factors and proteins onto the non-carbohydrate sulfated matrix followed by elution of such factors and proteins onto the non-carbohydrate sulfated matrix followed by elution of such factors and proteins from the matrix.

Abstract: There is disclosed a process for producing a convalently bound heparin--antithrombin-III complex useful for anticoagulant therapy, a covalently bound heparin--antithrombin-III complex produced by the process, a composition thereof in a pharmaceutically acceptable carrier, and a method for preventing and treating thromboembolisms by administering to a human patient a therapeutically effective amount of the complex or preparation.

Abstract: A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein. In this manner, heparin can be fractionated into high activity and low activity components.

Abstract: A complex of antithrombin and high activity heparin is provided for use as a potent anticoagulant for humans. The complex is prepared by reversibly immobilizing it on a lectin-containing, water-insoluble gel matrix and then removing it from the matrix.

Abstract: A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein. In this manner, heparin can be fractionated into high activity and low activity components.

Abstract: A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein.

Abstract: A system for monitoring the operation of a plurality of rotating-shaft machines, including a switchable meter to indicate the shaft speed of any one of these machines. Each machine has a monitoring circuit including respective visual warning branch circuits to indicate if the machine shaft falls below a first preset speed and then to indicate if the machine shaft falls below a second preset speed, with provision for sounding an audible alarm. The system has a single power supply, switchable meter, audible alarm control circuit and warning reset circuit, and identical monitor modules for the respective machines to be monitored. Each module has an external sensor, consisting of a pickup coil and a magnet assembly attached to the rotating shaft of the monitored machine; a high-gain integrated circuit amplifier to amplify the pulses from the sensor; circuitry to convert the pulses to a D.C.