Publication number: 20240390672
Abstract: Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) by delivering specialized pulsed electric field (PEF) energy to target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing thermal ablation). Consequently, when extracellular matrices present, the extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to target tissue throughout the body, particularly in locations previously considered inaccessible to percutaneous approaches.
Type:
Application
Filed:
January 18, 2024
Publication date:
November 28, 2024
Applicant:
Galvanize Therapeutics, Inc.
Inventors:
Robert E. Neal, William S. Krimsky, Seth S. Gleiman, Nicholas S. Mercer, Timothy J. O'Brien, Quim Castellvi, Johnathan R. Waldstreicher, Kevin J. Taylor, Luis L. Mangual Arbelo, Chiara Pastori, Ebtesam He Nafie, Mukta S. Wagh