Patents by Inventor Robert E. Polomski

Robert E. Polomski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for and intermediates in the preparation of canfosfamide and its salts
    Patent number: 8334266
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: December 18, 2012
    Assignee: Telik, Inc.
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS
    Publication number: 20120238772
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 20, 2012
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernández Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • Process for direct isolation of captopril
    Patent number: 5026873
    Abstract: A process is disclosed for direct isolation of captopril from a substrate of the formula ##STR1## wherein R is lower alkyl or lower alkoxy. In this process, the substrate is first treated with an aqueous alkali metal hydroxide capable of forming a water-soluble salt of the substrate, wherein the alkali metal hydroxide has a concentration of 4M or greater. The substrate is then neutralized, preferably with a mineral acid. By this process, captopril may be directly crystallized from an aqueous solution, avoiding the prior art use of organic solvents and zinc treatment to reduce levels of sulfide and disulfide impurities, respectively. In an alternative embodiment, neutralization is carried out by use of a hydrogen-supplying ion exchange resin.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: June 25, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, David A. Lust, Barbara J. Bennett, Alan F. Feldman, Robert E. Polomski
  • Combined process for heavy oil upgrading and synthetic fuel production
    Patent number: 4452691
    Abstract: A process for upgrading heavy oil to fuel products comprises deasphalting the heavy oil with an oxygenated solvent and simultaneously converting the oxygenated solvent and deasphalted oil over a ZSM-5 type catalyst to produce gasoline and distillate boiling range hydrocarbons.
    Type: Grant
    Filed: March 17, 1983
    Date of Patent: June 5, 1984
    Assignee: Mobil Oil Corporation
    Inventor: Robert E. Polomski